Diagnosis of twin zygosity by hypervariable RFLP markers.


The application of variable number of tandem repeat (VNTR) markers to the determination of twin zygosity was investigated. In the first case, which was performed with the use of six VNTR markers, the probability of monozygosity, calculated from Essen-Möller's formula II, was 0.99972. In the other three cases in which four VNTR markers were analyzed, the probabilities were 0.98251-0.99557. These results suggest that VNTR markers are useful for determination of twin zygosity.

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@article{Akane1991DiagnosisOT, title={Diagnosis of twin zygosity by hypervariable RFLP markers.}, author={Atsushi Akane and Kazuo Matsubara and Hiroshi Shiono and M Yamada and Yasuo Nakagome}, journal={American journal of medical genetics}, year={1991}, volume={41 1}, pages={96-8} }