Diagnosis of symptomatic gastroesophageal reflux disease

  title={Diagnosis of symptomatic gastroesophageal reflux disease},
  author={Peter J. Kahrilas},
  journal={American Journal of Gastroenterology},
Gastroesophageal reflux disease (GERD) encompasses a heterogeneous group of patients with differences in sensitivity to esophageal acid exposure, perception of pain, and physiological tissue involvement. The most difficult patients to understand are those who have a great symptom burden but no endoscopic evidence of esophageal mucosal involvement. These patients with symptomatic GERD (also called nonerosive reflux disease and endoscopy-negative reflux disease) present a diagnostic challenge… CONTINUE READING
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