Diagnosis of sickle-cell disease by DNA analysis in Nigeria.


OBJECTIVE To compare genotyping of leucocyte DNA by PCR and Dde I with the conventional genotyping of haemoglobin of the same subject. DESIGN Comparative study. SUBJECTS 25 adults, 16 males and nine females. MAIN OUTCOME MEASURES Predictability. RESULTS In all cases the results were comparable. CONCLUSIONS The technology can be applied locally to… (More)


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