Diagnosis of miscarriages by molecular karyotyping: Benefits and pitfalls

@article{Robberecht2009DiagnosisOM,
  title={Diagnosis of miscarriages by molecular karyotyping: Benefits and pitfalls},
  author={Caroline Robberecht and Vicky Schuddinck and J E Fryns and Joris Robert Vermeesch},
  journal={Genetics in Medicine},
  year={2009},
  volume={11},
  pages={646-654}
}
Purpose: About 50% of spontaneous abortions are caused by fetal chromosome abnormalities. Identification of these abnormalities helps to estimate recurrence risks in future pregnancies. However, due to culture failures or maternal contamination often no fetal karyotype can be obtained. Array comparative genomic hybridization can overcome some of these limitations.Methods: In this study, we analyzed 103 miscarriages by both T-banding and 1-Mb array comparative genomic hybridization.Results: We… CONTINUE READING