Diagnosis of invasive pneumococcal infection by PCR amplification of Streptococcus pneumoniae genomic fragments in blood: a multi-centre comparative study.

@article{Sheppard2003DiagnosisOI,
  title={Diagnosis of invasive pneumococcal infection by PCR amplification of Streptococcus pneumoniae genomic fragments in blood: a multi-centre comparative study.},
  author={Carmen L Sheppard and Timothy Guy Harrison and Angela M. Kearns and Malcolm Guiver and Marjorie Creek and Rachel E Evans and Michael D. Smith and Gary J.A. Eltringham and K. V. Cartwright and Robert C. George},
  journal={Communicable disease and public health},
  year={2003},
  volume={6 3},
  pages={221-7}
}
The increasing interest in the prevention of pneumococcal disease by immunisation necessitates improved organism-specific surveillance. This is particularly the case with regard to the contribution of Streptococcus pneumoniae infection to community-acquired pneumonia where blood cultures are often negative and sputum culture results ambiguous. Examination by PCR of blood samples taken at hospital admission offers one possibility for such improvement. The sensitivity, specificity and convenience… CONTINUE READING