Diagnosis of invasive aspergillosis using bronchoalveolar lavage in haematology patients: influence of bronchoalveolar lavage human DNA content on real-time PCR performance

@article{Fralle2008DiagnosisOI,
  title={Diagnosis of invasive aspergillosis using bronchoalveolar lavage in haematology patients: influence of bronchoalveolar lavage human DNA content on real-time PCR performance},
  author={E Fr{\'e}alle and K. Decrucq and Françoise Botterel and Brigitte Bouchindhomme and D. Camus and Eduardo Dei-Cas and Jackson M. Costa and Ibrahim Yakoub-Agha and St{\'e}phane Bretagne and Laurence Delha{\`e}s},
  journal={European Journal of Clinical Microbiology & Infectious Diseases},
  year={2008},
  volume={28},
  pages={223-232}
}
In order to improve invasive pulmonary aspergillosis (IPA) diagnosis, a real-time polymerase chain reaction (PCR) assay detecting Aspergillus spp. was developed. Its detection limit reached 2–20 conidia. The retrospective evaluation on 64 bronchoalveolar lavage (BAL) fluids from 57 patients at risk for IPA, including 20 probable and five proven IPA patients, revealed a 88% or 38% sensitivity in direct examination (DE)/culture-positive or culture-negative BAL, respectively, whereas galactomannan… CONTINUE READING

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clinical results

  • D Buchheidt, C Baust, +4 authors reaction bronchoalveolar lavage samples from immunocompromi chain
  • Clin Infect Dis 33(4):428–435. doi:10.1086/321887…
  • 2009

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