Diagnosis of human prion disease.


With the discovery of the prion protein (PrP), immunodiagnostic procedures were applied to diagnose Creutzfeldt-Jakob disease (CJD). Before development of the conformation-dependent immunoassay (CDI), all immunoassays for the disease-causing PrP isoform (PrPSc) used limited proteolysis to digest the precursor cellular PrP (PrPC). Because the CDI is the only… (More)


Cite this paper

@article{Safar2005DiagnosisOH, title={Diagnosis of human prion disease.}, author={Jiri G Safar and Michael D. Geschwind and Camille Deering and Svetlana Didorenko and Mamta Sattavat and Henry Sanchez and Ana V Serban and Martin Vey and Henry Baron and Kurt Giles and Bruce L. Miller and Stephen J. DeArmond and Stanley B Prusiner}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2005}, volume={102 9}, pages={3501-6} }