Diagnosis of human prion disease.

  title={Diagnosis of human prion disease.},
  author={Jiri G Safar and Michael D. Geschwind and Camille Deering and Svetlana Didorenko and Mamta Sattavat and Henry Sanchez and Ana V. Serban and Martin Vey and Henry Baron and Kurt Giles and Bruce L. Miller and Stephen J. DeArmond and Stanley B Prusiner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 9},
With the discovery of the prion protein (PrP), immunodiagnostic procedures were applied to diagnose Creutzfeldt-Jakob disease (CJD). Before development of the conformation-dependent immunoassay (CDI), all immunoassays for the disease-causing PrP isoform (PrPSc) used limited proteolysis to digest the precursor cellular PrP (PrPC). Because the CDI is the only immunoassay that measures both the protease-resistant and protease-sensitive forms of PrPSc, we used the CDI to diagnose human prion… CONTINUE READING


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