Diagnosis of hepatitis E

@article{Aggarwal2013DiagnosisOH,
  title={Diagnosis of hepatitis E},
  author={R. Aggarwal},
  journal={Nature Reviews Gastroenterology \&Hepatology},
  year={2013},
  volume={10},
  pages={24-33}
}
  • R. Aggarwal
  • Published 2013
  • Medicine
  • Nature Reviews Gastroenterology &Hepatology
Hepatitis E, caused by infection with hepatitis E virus (HEV), is a common cause of enterically-transmitted acute hepatitis in developing countries. Occasional cases of sporadic hepatitis E have been increasingly recognized in developed countries over the past decade. These cases differ from those in developing countries in being possibly caused by zoonotic transmission, often affecting people with a suppressed immune system and occasionally leading to persistent HEV infection. The commonly… Expand
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TLDR
There is an urgent need to develop better assays for markers of HEV infection and exposure, with low concordance, making comparisons of seroprevalence rates using different assays difficult to interpret. Expand
Hepatitis E virus.
TLDR
The specific etiology of cases of hepatitis E infection can be diagnosed by serological testing and detecting viral RNA, and Ribavirin is currently the reference treatment for HEV infections in immunocompromised patients. Expand
Hepatitis E virus infection
TLDR
HEV infections can be diagnosed by measuring anti-HEV antibodies, HEV RNA or viral capsid antigen in blood or stool and management of immunocompromised individuals involves lowering the dose of immunosuppressive drugs and/or treatment with the antiviral agent ribavirin. Expand
Epidemiology of Hepatitis E.
TLDR
A subunit vaccine has been shown to be effective in preventing clinical disease and has been licensed in China and has the highest attack rate in young adults, and the disease is particularly severe among pregnant women. Expand
Hepatitis E Virus
TLDR
Vaccine has been recently licensed for use in China and provides protection against hepatitis E for up to 4.5 years, and treatment of choice for chronic HEV infections is a 3-month course of ribavirin. Expand
Laboratory Diagnosis of HEV Infection.
TLDR
Although significant progress has been made in developing and optimizing different formats of HEV assays, improving their sensitivity and specificity, there are many shortcomings and challenges in inter-assay concordance, validation, and standardization. Expand
Hepatitis e: epidemiology and natural history.
  • R. Aggarwal
  • Medicine
  • Journal of clinical and experimental hepatology
  • 2013
TLDR
In areas with high disease endemicity, primarily developing countries in Asia and Africa, the disease occurs as outbreaks and as sporadic cases of acute hepatitis, and is caused exclusively by infection with genotypes 1 or 2 HEV, which is acquired through fecal-oral route, usually through contamination of water supplies. Expand
Epidemiologic concerns and advances in knowledge on hepatitis E.
TLDR
Travel-associated hepatitis E is seen more often among immigrants residing in developed countries who visit their home countries where the disease is endemic, possibly because visits of such travellers to diseaseendemic areas are longer in duration and their likelihood of exposure to contaminated food or drink may be higher. Expand
Hepatitis E virus: do locally acquired infections in Australia necessitate laboratory testing in acute hepatitis patients with no overseas travel history?
TLDR
Pigs in Australia have been shown to be infected with HEV, which indicates the possibility of zoonotic transmission and the extent of locally acquired infection is not known, however it may be greater than expected and may necessitate laboratory testing in patients reporting no overseas travel. Expand
Chronic hepatitis E: a review of the literature
TLDR
Although chronic HEV infection can result in progressive severe liver failure and cirrhosis, diagnosis is often controversial because of the lack of specific diagnostic criteria. Expand
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