Diagnosis of canine lymphoid neoplasia using clonal rearrangements of antigen receptor genes.

@article{Burnett2003DiagnosisOC,
  title={Diagnosis of canine lymphoid neoplasia using clonal rearrangements of antigen receptor genes.},
  author={Robert Carlisle Burnett and William Vernau and Jaime F Modiano and Christine S. Olver and Peter Francis Moore and Anne C. Avery},
  journal={Veterinary pathology},
  year={2003},
  volume={40 1},
  pages={32-41}
}
Although the diagnosis of canine leukemia and lymphoma in advanced stages is usually uncomplicated, some presentations of the disease can be a diagnostic challenge. In certain situations, lymphoma and leukemia can be difficult to distinguish from a benign reactive proliferation of lymphocytes. Because clonality is the hallmark of malignancy, we have developed an assay that uses the polymerase chain reaction to amplify the variable regions of immunoglobulin genes and T-cell receptor genes to… CONTINUE READING
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