Diagnosis of bladder cancer using telomerase activity in voided urine.

Abstract

BACKGROUND AND PURPOSE Telomerase is an essential enzyme for cellular immortality and tumorigenesis. Reactivation of telomerase is associated with many primary cancers. We evaluated the accuracy of a modified immunodiagnostic technique based on the telomeric repeat amplification protocol (TRAP) assay, by semi-quantitative measurement of telomerase activity… (More)

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