Diagnosis of acute aortic dissection by D-dimer: the International Registry of Acute Aortic Dissection Substudy on Biomarkers (IRAD-Bio) experience.

@article{Suzuki2009DiagnosisOA,
  title={Diagnosis of acute aortic dissection by D-dimer: the International Registry of Acute Aortic Dissection Substudy on Biomarkers (IRAD-Bio) experience.},
  author={Toshiki Suzuki and Alessandro Distante and Antonella Zizza and Santi Trimarchi and Massimo Villani and Jorge Antonio Salerno Uriarte and Luigi de Luca Tupputi Schinosa and Attilio Renzulli and Federico Sabino and Richard N. Nowak and Ronald H. Birkhahn and Judd E. Hollander and Francis L. Counselman and Bhima R. Vijayendran and Eduardo Bossone and Kim Eagle},
  journal={Circulation},
  year={2009},
  volume={119 20},
  pages={
          2702-7
        }
}
BACKGROUND D-dimer has been reported to be elevated in acute aortic dissection. Potential use as a "rule-out" marker has been suggested, but concerns remain given that it is elevated in other acute chest diseases, including pulmonary embolism and ischemic heart disease. We evaluated the diagnostic performance of D-dimer testing in a study population of patients with suspected aortic dissection. METHODS AND RESULTS In this prospective multicenter study, 220 patients with initial suspicion of… CONTINUE READING

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