Diagnosis of Whipple Disease by Immunohistochemical Analysis A Sensitive and Specific Method for the Detection of Tropheryma whipplei ( the Whipple Bacillus ) in Paraffin-Embedded Tissue

@inproceedings{Baisden2002DiagnosisOW,
  title={Diagnosis of Whipple Disease by Immunohistochemical Analysis A Sensitive and Specific Method for the Detection of Tropheryma whipplei ( the Whipple Bacillus ) in Paraffin-Embedded Tissue},
  author={Blaire L. Baisden and Hubert L{\'e}pidi and Didier Raoult and Pedram Argani and John H. Yardley and John Stephen Dumler},
  year={2002}
}
Whipple disease is a rare infection characterized clinically by diarrhea, fever, weight loss, arthralgia, malabsorption, and other systemic manifestations. The etiologic agent, Tropheryma whipplei, has been cultured only rarely. By using a polyclonal rabbit antibody produced against a cultured strain of T whipplei, tissue sections from 18 patients with Whipple disease were studied. Specimens from patients with histologic mimics and other infections served as control specimens. Immunostaining… CONTINUE READING
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