Diagnosis of Primary HIV-1 Infection

@article{Daar2001DiagnosisOP,
  title={Diagnosis of Primary HIV-1 Infection},
  author={Eric S Daar and Susan J Little and J Pitt and J Santangelo and Pauline Ho and Nina T. Harawa and Peter R. Kerndt and Janis V. Giorgi and Jie Bai and Paula Gaut and Douglas D. Richman and Susan J. Mandel and S Nichols},
  journal={Annals of Internal Medicine},
  year={2001},
  volume={134},
  pages={25-29}
}
Primary HIV infection is characterized by diverse clinical symptoms (1, 2). Since patients with primary infection are just developing HIV antibodies, recognition of the syndrome in at-risk persons should prompt antibody testing as well as a virologic assay (3, 4). Diagnosing primary infection may decrease HIV transmission (5) and allow consideration of early treatment (2, 6). To date, the optimal patients to screen and the best algorithm for use of diagnostic tests have not been determined. The… 
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  • A. Coco
  • Medicine, Biology
    The Annals of Family Medicine
  • 2005
TLDR
Expanded testing for primary HIV infection with p24 antigen EIA with a 67% probability of being cost-effective at the baseline prevalence and a 71% probability at a prevalence of 1% may be a sound expenditure of health care resources.
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TLDR
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Missed opportunities for diagnosing primary HIV infection
TLDR
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TLDR
Estimates of the prevalence of primary HIV infection in symptomatic ambulatory patients with fever, rash, and pharyngitis can aid with development of clinical testing guidelines and clinical decisions around testing for acute HIV infection.
Prevalence and Correlates of Unknown HIV Infection among Patients Seeking Care in a Public Hospital Emergency Department
TLDR
In a sample of patients visiting a county ED, the relative prevalence of unknown HIV infection was modest and less than national estimates (25%).
Detection of Acute HIV Infection in Two Evaluations of a New HIV Diagnostic Testing Algorithm — United States, 2011–2013
The highly infectious phase of acute human immunodeficiency virus (HIV) infection, defined as the interval between the appearance of HIV RNA in plasma and the detection of HIV-1-specific antibodies,
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References

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The events leading to the acquisition of HIV and the initial clinical and diagnostic evaluation of 46 patients with primary HIV infection are summarized.
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TLDR
This systematic case-control study of p24 antigen screening in HIV-seronegative patients attending STD clinics in India identified unprotected sex with a CSW and a genital ulcer as independent risk factors associated with newly acquired HIV infection.
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TLDR
Clinical features at the time of acute human immunodeficiency virus type 1 (HIV-1) disease in 218 patients with documented symptomatic primary HIV-1 infection were described.
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TLDR
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TLDR
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TLDR
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