Diagnosis of Orthopedic Infection in Clinical Practice Using Tc-99m Sulesomab (Antigranulocyte Monoclonal Antibody Fragment Fab′2)

@article{Vicente2004DiagnosisOO,
  title={Diagnosis of Orthopedic Infection in Clinical Practice Using Tc-99m Sulesomab (Antigranulocyte Monoclonal Antibody Fragment Fab′2)},
  author={Angeles Vicente and M. I. Almoguera and Juan Carlos Dur{\'a}n Alonso and Aaron J. Heffernan and Alberto G{\'o}mez and Pablo Contreras and Jos{\'e} Mart{\'i}n-Com{\'i}n},
  journal={Clinical Nuclear Medicine},
  year={2004},
  volume={29},
  pages={781-785}
}
Objective: The aim of the study was to analyze the use of Tc-99m-labeled antigranulocyte monoclonal antibody fragment Fab′2 (SMab, Leukoscan) in the diagnosis of acute osteomyelitis and articular prosthesis infection. One hundred seventeen patients (118 studies) have been included, 92 women and 25 men. Thirty-seven had a suspicion of osteomyelitis and 81 with suspicion of infection of a hip (35 patients) or a knee (45 patients) prosthesis. The mean age was 64 years. A 3-phase bone scan and a… Expand
26 Citations
Value of antigranulocyte scintigraphy with Tc-99m-sulesomab in diagnosing combat-related infections of the musculoskeletal system
TLDR
Three-phase bone scanning did not deliver any diagnostic benefit, since no result was able to differentiate unequivocally between infection-related and reactive changes, and antigranulocyte scintigraphy using Tc-99m-sulesomab represented a highly suitable technique for diagnostically clarifying combat-related infections of the extremities. Expand
Detection of low-grade prosthetic joint infections using 99mTc-antigranulocyte SPECT/CT: initial clinical results
TLDR
Relative to planar scintigraphy, SPECT with and without CT substantially improved the utility of imaging with 99mTc-labelled antigranulocyte antibodies for diagnosis and localization of suspected joint infections. Expand
Use of 99mTc-Sulesomab for the Diagnosis of Prosthesis Infection after Total Joint Arthroplasty
TLDR
It was showed that 99mTc-sulesomab had good diagnostic value for the detection of prosthesis infection and the combination of 99mSulesomAB with other laboratory or imaging examinations may improve diagnostic performance in prostheses infection and should be investigated further. Expand
Use of Anti-Granulocyte Scintigraphy with 99mTc-Labeled Monoclonal Antibodies for the Diagnosis of Periprosthetic Infection in Patients after Total Joint Arthroplasty: A Diagnostic Meta-Analysis
TLDR
Anti-granulocyte scintigraphy using 99 mTc-labeled monoclonal antibodies has a reasonable role in the diagnosis of PJI after total joint arthroplasty and additional high-quality original studies are required to confirm the predictive value. Expand
Osteomyelitis: antigranulocyte scintigraphy with 99mTC radiolabeled monoclonal antibodies for diagnosis-- meta-analysis.
TLDR
Antigranulocyte scintigraphy with MoAbs has a sensitivity of 81% and a specificity of 77% in the diagnosis of osteomyelitis and was better for peripheral than for axial skeleton lesions. Expand
Prosthesis infection: diagnosis after total joint arthroplasty with antigranulocyte scintigraphy with 99mTc-labeled monoclonal antibodies--a meta-analysis.
TLDR
AGS with monoclonal antibodies had a reasonably high discriminating ability to identify prosthesis infection in patients who underwent total joint arthroplasty. Expand
A meta-analysis of fluorodeoxyglucose-positron emission tomography versus scintigraphy in the evaluation of suspected osteomyelitis
TLDR
Leukocyte scintigraphy can be used with satisfactory diagnostic accuracy for detecting osteomyelitis when positron emission tomography systems are not available and the FDG-PET appears to be superior in terms of accuracy compared with other radionuclide imaging modalities. Expand
Imaging tests for the detection of osteomyelitis: a systematic review.
TLDR
Osteomyelitis is reliably diagnosed by MRI, PET and SPECT, and no clear reason to prefer one test over the other in terms of diagnostic accuracy was identified. Expand
Update on functional imaging in the evaluation of diabetic foot infection.
TLDR
The evolution of functional nuclear medicine imaging including immunoscintigraphy in diabetic foot infection is described and current applications of physiological 18-Fluoro-deoxyglucose positron emission tomography and computed tomography (18-FDG-PET/CT) in such patients are highlighted. Expand
Chronic Recurrent Multifocal Osteomyelitis in Children: A Multidisciplinary Approach is needed to establish a Diagnosis
TLDR
A 6-year-old girl diagnosed with CRMO involving tibia and lumbar vertebra is presented where a multidisciplinary approach was essential in making the diagnosis. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 27 REFERENCES
Detection of soft-tissue infections and osteomyelitis using a technetium-99m-labeled anti-granulocyte monoclonal antibody fragment.
TLDR
Investigation of the use of 99mTc-murine anti-granulocyte monoclonal Fab' fragment in patients with suspected osteomyelitis of soft-tissue infections found it offers rapid localization of foci, rapid and simple use, a negligible HAMA response rate, no effect on granulocyte function and an accuracy comparable to WBC scanning. Expand
Comparative Study of Monoclonal Antibody Scan in Diagnosing Orthopaedic Infection
TLDR
LeukoScan is more accurate in detecting osteomyelitis, with better sensitivity and specificity in prosthetic joints, and results are obtained in 1 to 6 hours without biohazard risk from handling blood products. Expand
LeukoScan for Imaging Infection in Different Clinical Settings: A Retrospective Evaluation and Extended Review of the Literature
TLDR
Tc-99m–labeled antigranulocyte monoclonal antibody Fab’ fragments can be used for imaging acute infections of peripheral bones and soft tissues and can be increased while decreasing specificity by including photopenic lesions in the spine as diagnostic criteria for localizing disease. Expand
Rapid imaging of infections with a monoclonal antibody fragment (LeukoScan).
TLDR
LeukoScan is suitable for imaging infectious lesions and may have diagnostic advantages compared with autologous leukocyte scintigraphy and human antimouse antibody could not be detected in any of the 13 patients tested 1 or 3 months after injection. Expand
Comparison of Tc-99m-labelled antileukocyte fragment Fab′ and Tc-99m-HMPAO leukocyte scintigraphy in the diagnosis of bone and joint infections: a prospective study
TLDR
The interpretation of LEUKOSCAN® scintigraphy is more difficult than HMPAO-LS for the diagnosis of bone infection in the diabetic foot, and would appear to be less discriminating for differentiating soft tissue infection from osteitis in the case of plantar perforating ulcers. Expand
Imaging of low-grade bone infection with a technetium-99m labelled monoclonal anti-NCA-90 Fab' fragment in patients with previous joint surgery
TLDR
MN3 Fab' scintigraphy proved to be highly sensitive but not specific in diagnosing low-grade infections of the hip and knee regions in patients with previous joint surgery, and the method seems reliable in excluding but not in proving the presence of infection. Expand
Use of Sulesomab, a radiolabeled antibody fragment, to detect osteomyelitis in diabetic patients with foot ulcers by leukoscintigraphy.
TLDR
Sulesomab is an effective and rapid imaging agent that is diagnostically comparable or superior to WBC scans in this setting, with significant advantages in safety and ease of use. Expand
Gammagrafía con 99mTc-coloide de estaño en la valoración de la infección de los implantes ortopédicos
TLDR
The results show that the bone marrow scintigraphy with 99mTc-stannous colloid improves the accuracy of the diagnostic of bone prosthesis infection and should be included into the diagnosis protocol of this disease. Expand
Clinical evaluation of technetium-99m infecton for the localisation of bacterial infection
TLDR
It is concluded that99mTc-Infecton imaging contributed to the differential diagnosis of inflammation and is being used as the first imaging modality when bacterial infection is suspected. Expand
Rapid diagnostic imaging of acute, nonclassic appendicitis by leukoscintigraphy with sulesomab, a technetium 99m-labeled antigranulocyte antibody Fab' fragment. LeukoScan Appendicitis Clinical Trial Group.
TLDR
Sulesomab is safe, well-tolerated, and with no apparent immunogenicity, especially by correctly predicting surgery to be unnecessary in 97% of patients without acute appendicitis, and management decisions incorporating sulesomAB imaging potentially provide clear patient benefits. Expand
...
1
2
3
...