Diagnosis of Human Prion Disease Using Real-Time Quaking-Induced Conversion Testing of Olfactory Mucosa and Cerebrospinal Fluid Samples

  title={Diagnosis of Human Prion Disease Using Real-Time Quaking-Induced Conversion Testing of Olfactory Mucosa and Cerebrospinal Fluid Samples},
  author={M. Bongianni and Christina D Orr{\'u} and B. Groveman and L. Sacchetto and M. Fiorini and G. Tonoli and Giorgio Triva and S. Capaldi and S. Testi and S. Ferrari and A. Cagnin and A. Ladogana and A. Poleggi and E. Colaizzo and D. Tiple and Luana Vaianella and S. Castriciano and D. Marchioni and A. Hughson and D. Imperiale and T. Cattaruzza and G. M. Fabrizi and M. Pocchiari and S. Monaco and B. Caughey and G. Zanusso},
  journal={JAMA Neurology},
  • M. Bongianni, Christina D Orrú, +23 authors G. Zanusso
  • Published 2017
  • Medicine
  • JAMA Neurology
  • Importance Early and accurate in vivo diagnosis of Creutzfeldt-Jakob disease (CJD) is necessary for quickly distinguishing treatable from untreatable rapidly progressive dementias and for future therapeutic trials. This early diagnosis is becoming possible using the real-time quaking-induced conversion (RT-QuIC) seeding assay, which detects minute amounts of the disease-specific pathologic prion protein in cerebrospinal fluid (CSF) or olfactory mucosa (OM) samples. Objective To develop an… CONTINUE READING
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