Diagnosis and treatment of hepatocellular carcinoma.

@article{ElSerag2008DiagnosisAT,
  title={Diagnosis and treatment of hepatocellular carcinoma.},
  author={Hashem B. El‐Serag and Jorge Marrero and Lenhard K Rudolph and K. Rajender Reddy},
  journal={Gastroenterology},
  year={2008},
  volume={134 6},
  pages={
          1752-63
        }
}
The diagnosis and treatment of hepatocellular carcinoma (HCC) have witnessed major changes over the past decade. Until the early 1990s, HCC was a relatively rare malignancy, typically diagnosed at an advanced stage in a symptomatic patient, and there were no known effective palliative or therapeutic options. However, the rising incidence of HCC in several regions around the world coupled with emerging evidence for efficacy of screening in high-risk patients, liver transplantation as a curative… 

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