Diagnosis and treatment of celiac disease

  title={Diagnosis and treatment of celiac disease},
  author={Ludvig M. Sollid and Knut Erik Aslaksen Lundin},
  journal={Mucosal Immunology},
The understanding of the pathogenesis of celiac disease has made huge advances in recent years. The disease is caused by an inappropriate immune response to dietary gluten proteins. This immune response is controlled by CD4+ T cells in the lamina propria that recognize gluten peptides in the context of disease predisposing HLA-DQ2 and HLA-DQ8 molecules.1, 2 These T cells are specific for proline- and glutamine-rich gluten peptides that are resistant to proteolysis and that have been become… CONTINUE READING
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