Diagnosis and treatment in the early illness phase of bipolar disorders

  title={Diagnosis and treatment in the early illness phase of bipolar disorders},
  author={Michael Bauer and Georg Juckel and Christoph U. Correll and Karolina Leopold and Andrea Pfennig},
  journal={European Archives of Psychiatry and Clinical Neuroscience},
The combination of a long undetected illness and significant psychosocial impairment renders early identification and intervention a vital role in bipolar disorders. Early detection forms the basis for adequate education and for treatment from the beginning. Several lines of evidence indicate that the characterization of early phases in the development of bipolar disorders is feasible. Risk factors for the development of bipolar disorders have been established and a manic prodrome has been… 
[Early recognition and intervention for bipolar disorders: state of research and perspectives].
A German-speaking network of scientists in the fields of bipolar disorders and early recognition of mental disorders ("Network for Early Recognition and Intervention in Bipolar Disorders", short: NERIBID") is founded in order to develop joint scientific and clinical standards and design and conduct collaborative study projects.
Early Recognition of High Risk of Bipolar Disorder and Psychosis: An Overview of the ZInEP “Early Recognition” Study
The rationale and design of a prospective longitudinal study focused on at-risk states of psychosis and bipolar disorder, carried out within the context of the Zurich Program for Sustainable Development of Mental Health services are provided.
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There is currently little evidence for interventions in these stages of BD, and case management; individual, group, and family therapy; supportive therapy; and group psychoeducation programs have been proposed.
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Duration of Untreated Psychosis and Duration of Untreated Illness: New Vistas
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Clinical features and patterns of psychopharmacological prescription in bipolar patients with vs without anxiety disorders at onset
Prevalence of AD subtypes as first psychiatric manifestations and AD's relations with duration of untreated illness (DUI) and treatment among BD outpatients are investigated.
A comprehensive review and model of putative prodromal features of bipolar affective disorder
Clinical features preceding the onset of BD can be identified, however, conclusions about whether there is a distinct prodrome to BD are restricted by the limitations of current evidence.
Psychotherapeutic interventions in individuals at risk of developing bipolar disorder: a systematic review
The evidence for psychotherapeutic treatments in help‐seeking individuals considered at risk for BD (At‐Risk‐BD) is reviewed to help clarify the need for early preventive interventions in BD.
[Bipolar depression. Epidemiology, etiopathogenesis, and course].
Current knowledge regarding epidemiology, etiopathogenesis, and course of bipolar Disorder with a focus on depression of bipolar disorder is described.
Dropout rate and associated factors in patients with bipolar disorders.


Early intervention in bipolar disorders: opportunities and pitfalls
The notion of neuroprotection reflects this, and furthermore suggests that appropriate therapy may prevent the neurostructural and neurocognitive changes seen in the disorder.
Early recognition of bipolar disorder
Differentiation in the preonset phases of schizophrenia and mood disorders: evidence in support of a bipolar mania prodrome.
A lengthy and symptomatic prodrome makes clinical high-risk research a feasible goal for bipolar disorder and the phenotypic overlap with the schizophrenia prodrome necessitates the concurrent study of both illness prodromes.
Prodromal symptoms before onset of manic-depressive disorder suggested by first hospital admission histories.
The data suggest testable hypotheses about specific symptoms and behaviors that may be useful for the early detection of children at highest risk for developing manic-depressive disorder.
The proximal prodrome to first episode mania--a new target for early intervention.
Current knowledge on the early phase of bipolar disorders is gathered in order to define new targets for early intervention and it is likely that an approach aiming at the identification of impending first-episode mania is the most realistic and manageable strategy to promote earlier treatment.
Early identification and high-risk strategies for bipolar disorder.
Given the current limitations of each early identification method, combining clinical, endophenotypic and genetic strategies will increase prediction accuracy.
The early manifestations of bipolar disorder: a longitudinal prospective study of the offspring of bipolar parents.
Despite a specific genetic risk, BD began with non-specific psychopathology and/or depressive disorders in a majority of offspring and diagnosis based only on cross-sectional assessment of symptoms appears to be insufficient for the accurate early detection of emerging BD.
Early Developmental Stages of Psychopathology Study (EDSP): Objectives and Design
The primary and secondary objectives of the Early Developmental Stages of Substance Abuse Study (EDSP) are described along with a detailed description of the overall design, special design features