Diagnosis and screening of autosomal dominant polycystic kidney disease.

@article{Pei2010DiagnosisAS,
  title={Diagnosis and screening of autosomal dominant polycystic kidney disease.},
  author={York P Pei and Terry J. Watnick},
  journal={Advances in chronic kidney disease},
  year={2010},
  volume={17 2},
  pages={140-52}
}
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited cause of kidney failure and accounts for approximately 5% of ESRD population in the United States. The disorder is characterized by the focal and sporadic development of renal cysts, which increase in size and number with age. Mutations of PKD1 and PKD2 account for most of the cases. Although the clinical manifestations of both gene types overlap completely, PKD1 is associated with more severe disease than PKD2… CONTINUE READING