Diagnosis and prevention of chronic kidney allograft loss

@article{Nankivell2011DiagnosisAP,
  title={Diagnosis and prevention of chronic kidney allograft loss},
  author={Brian J Nankivell and Dirk R J Kuypers},
  journal={The Lancet},
  year={2011},
  volume={378},
  pages={1428-1437}
}
Chronic renal allograft dysfunction: risk factors, immunology and prevention.
TLDR
Evidence-based treatment strategies for chronic allograft dysfunction are lacking, but several prevention and management strategies are recommended in clinical practice.
Challenges and considerations in diagnosing the kidney disease in deteriorating graft function
  • H. Ekberg, M. Johansson
  • Medicine
    Transplant international : official journal of the European Society for Organ Transplantation
  • 2012
Despite significant reductions in acute‐rejection rates with the introduction of calcineurin inhibitor (CNI)‐based immunosuppressive therapy, improvements in long‐term graft survival in renal
Lifestyle, Inflammation, and Vascular Calcification in Kidney Transplant Recipients: Perspectives on Long-Term Outcomes
TLDR
Modifiable dietary elements and toxic environmental contaminants that may explain increased risk of cardiovascular mortality and late graft failure in kidney transplant recipients (KTR) are discussed.
Prevention of cardiovascular disease after renal transplantation
TLDR
To prevent CVD in renal transplant recipients, cardiovascular risk assessment should be performed regularly and prevention should include both lifestyle modifications, optimal treatment of cardiovascular risk factors and strategies to preserve graft function.
Has the survival of the graft improved after renal transplantation in the era of modern immunosuppression?
TLDR
This review analyses some of the evidences conditioning graft failure as well as related therapeutic and prognostic aspects, and identifies the causes of graft failure and its risk factors, applying predictive models, and intervening in causal factors could constitute strategies for improving kidney transplantation results in terms of survival.
Eculizumab in renal transplantation.
Factors influencing long‐term outcome after kidney transplantation
TLDR
Although current immunosuppression regimes are highly efficient in preventing acute rejection, the burden of specific (diabetes, nephrotoxicity) and nonspecific side effects has significant negative long‐term consequences that may well be worse in the future because of the increasing ages of both donors and recipients.
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