Diagnosis and management of the epilepsies in adults and children: summary of updated NICE guidance

  title={Diagnosis and management of the epilepsies in adults and children: summary of updated NICE guidance},
  author={Vanessa Delgado Nunes and Laura M Sawyer and Julie Neilson and Grammati Sarri and Judith Helen Cross},
  journal={BMJ : British Medical Journal},
Epilepsy is a common neurological disorder characterised by recurring epileptic seizures; it is not a single diagnosis but is a symptom with many underlying causes, more accurately termed the epilepsies. Antiepileptic drugs (AEDs) to prevent recurrence of seizures form the mainstay of treatment. Diagnosis can be challenging, making accurate prevalence estimates difficult. With a prevalence of active epilepsy of 5-10 cases per 1000,1 epilepsy has been estimated to affect between 362 000 and 415… 

Diagnosis and management of the epilepsies in children: a summary of the partial update of the 2012 NICE epilepsy guideline

This partial update provides additional data and also specific recommendations that improve the evidence base for the use of specific anti-epileptic drugs in treating the epilepsies of childhood.

Treatment of pediatric epilepsy in Poland.

Adult epilepsy and anaesthesia

All anaesthetists will regularly encounter patients with epilepsy in their practice and should be aware of the special considerations when managing patients with this disorder, and Planned and thoughtful care of these patients can minimize the risk of seizure occurrence in the perioperative period.

Supportive principles in the pharmacological management of the patients with epilepsy

Management of epilepsy means more than observing the medication prescribed by the specialist, it is also important for the patient to maintain his general health status, monitor the symptoms of epilepsy and response to treatment and take care of his safety.

Neuroimaging of Early Life Epilepsy

Structural abnormalities occur commonly in ELE, and adherence to neuroimaging guidelines is high at US pediatric epilepsy centers, support the universal adoption of imaging guidelines because the yield is substantially high, even in the lowest risk group.

Pharmacological management of seizures in patients with COVID-19: a systematic review

Standard guidelines for managing seizures in COVID-19 patients may be required after it was found that none of the patients who received no AEDs suffered recurrent seizures or died.

Prevalence and patterns of anti‐epileptic medication prescribing in the treatment of epilepsy in older adults with intellectual disabilities

The findings indicated that people with ID and epilepsy were often exposed to psychotropic medications that may lower the seizure threshold, and despite the use of AED therapy, over half had seizures in the previous 2 years.

The effect of epilepsy control on psychogenic non epileptic seizures

Diagnostic utility of cerebrospinal fluid analysis in dogs with suspected idiopathic epilepsy.

CSF analysis can play an important role in the diagnostic investigation of the underlying causes of repeated seizures, however, in dogs with a normal inter-ictal neurological examination and MRI scan, it rarely reveals significant abnormalities, and the risk of performing a CSF tap may outweigh the potential diagnostic gain.

Treatment and challenges with antiepileptic drugs in patients with juvenile myoclonic epilepsy




The pharmacological treatment of epilepsy in adults

Clinical trials of antiepileptic medications in newly diagnosed patients with epilepsy

None of the newer AEDs has shown superior efficacy when tested against established agents for the treatment of partial seizures and generalized tonic–clonic seizures, the most common seizure types.

Placebo‐corrected efficacy of modern antiepileptic drugs for refractory epilepsy: Systematic review and meta‐analysis

It is concluded that the placebo‐corrected efficacy of adjunctive treatment with modern AEDs is disappointingly small and suggest that better strategies of finding drugs are needed for refractory epilepsy, which is a major public health problem.

Antiepileptic drugs—best practice guidelines for therapeutic drug monitoring: A position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies

Evidence from nonrandomized studies and everyday clinical experience does indicate that measuring serum concentrations of old and new generation antiepileptic drugs (AEDs) can have a valuable role in guiding patient management provided that concentrations are measured with a clear indication and are interpreted critically, taking into account the whole clinical context.

Management issues for women with epilepsy.

Antiepileptic drugs (AED) have been known to cause bone mass loss for many years, yet anticonvulsant-induced osteoporosis remains unrecognized by the vast majority of the medical community.

Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies

It is proposed as a testable hypothesis that drug resistant epilepsy is defined as failure of adequate trials of two tolerated, appropriately chosen and used antiepileptic drug schedules to achieve sustained seizure freedom.

Revised terminology and concepts for organization of seizures and epilepsies: Report of the ILAE Commission on Classification and Terminology, 2005–2009

The International League Against Epilepsy (ILAE) Commission on Classification and Terminology has revised concepts, terminology, and approaches for classifying seizures and forms of epilepsy.