Diagnosis and management of primary sclerosing cholangitis

@article{Chapman2010DiagnosisAM,
  title={Diagnosis and management of primary sclerosing cholangitis},
  author={Roger William Chapman and Johan Fevery and Anthony N. Kalloo and David M. Nagorney and Kirsten Muri Boberg and Benjamin L. Shneider and Gregory J. Gores},
  journal={Hepatology},
  year={2010},
  volume={51}
}
Preamble This guideline has been approved by the American Association for the Study of Liver Diseases and represents the position of the Association. These recommendations provide a data-supported approach. They are based on the following: (1) formal review and analysis of the recentlypublished world literature on the topic (Medline search); (2) American College of Physicians Manual for Assessing Health Practices and Designing Practice Guidelines1; (3) guideline policies, including the AASLD… 
Current consensus on the management of primary sclerosing cholangitis.
Current consensus on the management of primary sclerosing cholangitis
ummary Guidelines for the management of primary sclerosing cholangitis (PSC) have recently een published by both the European Association for the Study of the Liver (EASL) and the merican Association
Clinical guidelines for primary sclerosing cholangitis 2017
TLDR
Clinical guidelines to manage patients with PSC were made based on the literature review and expert opinions and it is hoped that these guidelines will contribute to the improvement and development of the medical care of PSC.
AASLD clinical practice guidelines: A critical review of scientific evidence and evolving recommendations
TLDR
Despite significant increases in the numbers of recommendations within AASLD practice guidelines over time, only a minority are supported by grade I evidence, highlighting the need for developing well‐designed investigations to provide evidence for areas of uncertainty and improving the quality of future guidelines in hepatobiliary diseases.
Diagnosis and Management of Autoimmune Hepatitis in Adults and Children: 2019 Practice Guidance and Guidelines From the American Association for the Study of Liver Diseases
TLDR
This practice guideline/guidance constitutes an update of the guidelines on AIH published in 2010 by the American Association for the Study of Liver Diseases (AASLD) and updates the epidemiology, diagnosis, management, and outcomes of AIH in adults and children.
urrent consensus on the management of primary clerosing cholangitis
ummary Guidelines for the management of primary sclerosing cholangitis (PSC) have recently een published by both the European Association for the Study of the Liver (EASL) and the merican Association
Primary sclerosing cholangitis : review of recommendations for diagnosis and treatment of disease
TLDR
This review analyzed recommendations of the leading gastroenterological (hepatological) associations on PSC and received the most complete comprehension on the features of diagnosis and treatment modalities for PSC at the present stage of the development of medicine.
Dominant strictures in primary sclerosing cholangitis: A multicenter survey of clinical definitions and practices
TLDR
Despite the prevalence and morbidity of DSs in PSC, clinical perceptions and practices vary widely among hepatologists, gastroenterologists, and advanced endoscopists who manage these patients, even within a single health care system.
Pharmacologic management of primary sclerosing cholangitis: what’s in the pipeline?
TLDR
The rarity of this condition and poor understanding of its pathophysiology have created a void for safe and effective treatment options to alter mortality or transplant free survival, Nevertheless, some agents currently being tested have demonstrated therapeutic potential.
Criteria Used in Clinical Practice to Guide Immunosuppressive Treatment in Patients with Primary Sclerosing Cholangitis
TLDR
A simplified autoimmune hepatitis score >5 and a mHAI score >3, suggesting concomitant features of AIH, influenced the decision to introduce IT during the course of PSC, and in German clinical practice, the cutoffs used to guide IT may be lower than recommended by current guidelines.
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References

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Review article: current management of primary sclerosing cholangitis
TLDR
Large international collaborations to study primary sclerosing cholangitis are necessary to provide clearer answers in areas of uncertainty, and these are now beginning to emerge.
The medical management of primary sclerosing cholangitis.
TLDR
The most studied drug in PSC is ursodeoxycholic acid, which, despite a range of potentially valuable actions on the cholestatic liver, has not yet been proven to make a substantial change in the course of the disease.
The Burden of Large and Small Duct Primary Sclerosing Cholangitis in Adults and Children: A Population-Based Analysis
TLDR
Pediatric cases and small duct PSC are less common than adult large duct P SC and the risk of developing PSC in UC and CD was similar, Surprisingly, the risk in Crohn's disease and ulcerative colitis was similar.
Endoscopic management of primary sclerosing cholangitis: review, and report of an open series.
TLDR
The various endoscopic treatment modalities utilized in PSC disease are discussed, and the results that have been obtained with these techniques since they were incorporated into the armamentarium in 1983 are included.
Endoscopic management of primary sclerosing cholangitis: review, and report of an open series.
TLDR
The various endoscopic treatment modalities utilized in PSC disease are discussed, and the results that have been obtained with these techniques since they were incorporated into the armamentarium in 1983 are included.
Expert pediatric opinion on the Report of the Baveno IV Consensus Workshop on Methodology of Diagnosis and Therapy in Portal Hypertension
TLDR
A panel of pediatric experts reviewed the most recent Baveno statement and crafted a statement modified with their opinions vis a vis approaches to the management of portal hypertension in children.
Natural history of primary sclerosing cholangitis and prognostic value of cholangiography in a Dutch population
TLDR
The observed survival in Dutch PSC patients with established PSC was considerably better than reported in earlier series from Sweden, the UK, and the USA.
Primary Sclerosing Cholangitis in Children: A Histologic Follow-up Study
TLDR
The experience with PSC at the Children’s Hospital of Philadelphia over the past 20 years was evaluated, with an emphasis on the histologic features at presentation, during disease progression, and after liver transplantation.
[Predictive factors for portal hypertension in patients with primary sclerosing cholangitis].
TLDR
There are noninvasive indicators of portal hypertension that could predict the presence of esophageal varices and risk of bleeding in patients with PSC and these patients should benefit from endoscopic surveillance.
Primary sclerosing cholangitis in 32 children: Clinical, laboratory, and radiographic features, with survival analysis
TLDR
Survival analysis indicated that a later age at presentation, splenomegaly, and prolonged prothrombin time at presentation were significant contributors to the prediction of poor outcome (i.e., death or listing for transplantation).
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