Diagnosis and management of patients with reflux symptoms refractory to proton pump inhibitors.

@article{Sifrim2012DiagnosisAM,
  title={Diagnosis and management of patients with reflux symptoms refractory to proton pump inhibitors.},
  author={Daniel A Sifrim and Frank Zerbib},
  journal={Gut},
  year={2012},
  volume={61 9},
  pages={
          1340-54
        }
}
Approximately a third of patients with suspected gastro-oesophageal reflux disease are resistant or partial responders to proton pump inhibitors (PPIs). Many of these patients do not have gastro-oesophageal reflux disease, but suffer from functional heartburn or dyspepsia. The potential mechanisms underlying failure of PPI treatment in patients with reflux-related symptoms include persistence of isolated or mixed acid, weakly acidic, bile or gas reflux, impaired oesophageal mucosal integrity… CONTINUE READING

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