Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus.

  title={Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus.},
  author={Aliya Aziz Khan and Archie D Morrison and David Arthur Hanley and Dieter Felsenberg and L. McCauley and Felice O'ryan and Ian R Reid and Salvatore L. Ruggiero and Akira Taguchi and Sotirios Tetradis and Nelson B. Watts and Maria Luisa Brandi and Edmund Peters and Teresa Guise and Richard Eastell and Angela M W Cheung and Suzanne Nicole Morin and Basel Masri and Cyrus Cooper and Sarah L. Morgan and Barbara Obermayer-Pietsch and Bente Lomholt Langdahl and Rana Al Dabagh and Kenneth Shawn Davison and David L. Kendler and George K. B. S{\'a}ndor and Robert G. Josse and Mohit Bhandari and Mohamed El Rabbany and Dominique D. Pierroz and Riad A. Sulimani and Deborah P. Saunders and Jacques P Brown and Juliet Compston},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  volume={30 1},
This work provides a systematic review of the literature from January 2003 to April 2014 pertaining to the incidence, pathophysiology, diagnosis, and treatment of osteonecrosis of the jaw (ONJ), and offers recommendations for its management based on multidisciplinary international consensus. ONJ is associated with oncology-dose parenteral antiresorptive therapy of bisphosphonates (BP) and denosumab (Dmab). The incidence of ONJ is greatest in the oncology patient population (1% to 15%), where… CONTINUE READING
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