Diagnosis and management of neonatal alloimmune thrombocytopenia.

  title={Diagnosis and management of neonatal alloimmune thrombocytopenia.},
  author={Donald M. Arnold and James W. Smith and John G. Kelton},
  journal={Transfusion medicine reviews},
  volume={22 4},
Neonatal alloimmune thrombocytopenia (NAT) is a life-threatening bleeding disorder caused by maternal platelet antibodies produced in response to fetal platelet antigens inherited from the father. Antiplatelet antibodies cross the placenta and cause destruction of fetal platelets, leading to severe thrombocytopenia, and potentially bleeding, including fatal intracerebral hemorrhage. Incompatibilities between maternal and fetal platelets for the human platelet antigen 1a (previously called PL(A1… CONTINUE READING
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