Diagnosis and management of maturity onset diabetes of the young (MODY)
@article{Thanabalasingham2011DiagnosisAM, title={Diagnosis and management of maturity onset diabetes of the young (MODY)}, author={Gaya Thanabalasingham and Katharine R. Owen}, journal={BMJ : British Medical Journal}, year={2011}, volume={343} }
#### Summary points
Maturity onset diabetes of the young (MODY) comprises a heterogeneous group of monogenic disorders characterised by β cell dysfunction. It is estimated to be the underlying cause of diabetes in 1-2% of patients diagnosed with diabetes, but prevalence estimates will not be accurate until large population screening studies are performed.1 It is important to distinguish MODY from type 1 and type 2 diabetes because optimal treatments are different. Furthermore, first degree…
160 Citations
Diagnosis and Treatment of MODY: An Updated Mini Review
- Medicine, BiologyApplied Sciences
- 2021
This review serves to explore MODY subtypes, diagnosis, and treatment, and increase awareness of MODY incidence to allow for more effective therapeutic management and treatment strategies that are distinct from those used for type 1 and type 2 diabetes.
Maturity onset diabetes of the young: clinical characteristics, diagnosis and management.
- MedicinePediatric endocrinology reviews : PER
- 2012
Raising awareness about MODY and making the diagnosis more accessible will improve prognostication and management of these patients and their relatives.
MODY Probability Ratios in Patients Diagnosed with Type 2 Diabetes Mellitus at a Young Age
- MedicineMedeniyet medical journal
- 2020
It has been reported that MODY risk calculated by MPC may yield different results in different populations, and the results of this study showed that 15% of young-onset diabetes patients had an MPC score above 20 percent.
Maturity-onset diabetes of the young (MODY): an update
- Medicine, BiologyJournal of pediatric endocrinology & metabolism : JPEM
- 2015
The main clinical and laboratory characteristics of the common and rarer causes of MODY are summarized.
Frequency and genetic spectrum of maturity-onset diabetes of the young (MODY) in southern New Zealand
- MedicineJournal of Diabetes & Metabolic Disorders
- 2013
These families highlight the features of three of the more common MODY subtypes, including two with novel mutations, one of which segregates in a kindred that is strongly affected by both MODY and classic autoimmune mediated diabetes.
Maturity-onset diabetes of the young: From a molecular basis perspective toward the clinical phenotype and proper management.
- Medicine, BiologyEndocrinologia, diabetes y nutricion
- 2019
Maturity onset diabetes of the young
- MedicineInnovAiT: Education and inspiration for general practice
- 2021
Basic information is presented about this rare, but rather important, genetic disorder that is linked to diabetes in younger people and awareness of this condition among primary care physicians should improve diagnosis.
Maturity onset diabetes of the young: Seek and you will find.
- Medicine, BiologyThe Netherlands journal of medicine
- 2016
It is shown that a doctor's clinical eye and taking the time for a detailed family history may be equal to, or even better than, the best prediction rule in finding patients in whom further genetic testing for possible MODY is warranted.
Maturity onset diabetes of young type 2 due to a novel de novo GKC mutation.
- Medicine, BiologyArquivos brasileiros de endocrinologia e metabologia
- 2014
A 13-year-old, healthy and non-obese girl was admitted for investigation of recurrent hyperglycemia episodes and a novel missense heterozygous mutation in exon 5 of GCK gene c.509G > T (p.Gly170Val) was identified, establishing the diagnosis of MODY type 2.
Maturity-onset diabetes of the young (MODY)-related genetic variants in a Turkish patient cohort with early-onset diabetes: a cross-sectional study
- Medicine, BiologyInternational Journal of Diabetes in Developing Countries
- 2022
It is presented that diabetic patients below 35 age, without low C-peptide levels and any positivity for beta-cell autoimmunity markers, must be screened for MODY gene panel for diagnosis and genetic counseling.
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OBJECTIVE Maturity-onset diabetes of the young (MODY) as a result of mutations in hepatocyte nuclear factor 1-α (HNF1A) is often misdiagnosed as type 1 diabetes or type 2 diabetes. Recent work has…
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