Diagnosis and management of dementia with Lewy bodies

@article{McKeith2005DiagnosisAM,
  title={Diagnosis and management of dementia with Lewy bodies},
  author={I. McKeith and D. Dickson and J. Lowe and M. Emre and J. O'Brien and H. Feldman and J. Cummings and J. Duda and C. Lippa and E. Perry and D. Aarsland and H. Arai and C. Ballard and B. Boeve and D. Burn and D. Costa and T. del Ser and B. Dubois and D. Galasko and S. Gauthier and C. Goetz and E. G{\'o}mez-Tortosa and G. Halliday and L. Hansen and J. Hardy and T. Iwatsubo and R. Kalaria and D. Kaufer and R. Kenny and A. Korczyn and K. Kosaka and V. Lee and A. Lees and I. Litvan and E. Londos and O. Lopez and S. Minoshima and Y. Mizuno and J. Molina and E. Mukaetova-Ladinska and F. Pasquier and R. Perry and J. Schulz and J. Trojanowski and M. Yamada},
  journal={Neurology},
  year={2005},
  volume={65},
  pages={1863 - 1872}
}
The dementia with Lewy bodies (DLB) Consortium has revised criteria for the clinical and pathologic diagnosis of DLB incorporating new information about the core clinical features and suggesting improved methods to assess them. REM sleep behavior disorder, severe neuroleptic sensitivity, and reduced striatal dopamine transporter activity on functional neuroimaging are given greater diagnostic weighting as features suggestive of a DLB diagnosis. The 1-year rule distinguishing between DLB and… Expand
Diagnosis and management of dementia with Lewy bodies
The Dementia with Lewy Bodies (DLB) Consortium has refined its recommendations about the clinical and pathologic diagnosis of DLB, updating the previous report, which has been in widespread use forExpand
Update on Dementia with Lewy Bodies
Dementia with Lewy bodies (DLB) is the second most common form of dementia after Alzheimer disease (AD). DLB is characterized pathologically by Lewy body and Lewy neuritic pathology, often withExpand
Dementia with Lewy bodies
Abstract Dementia with Lewy bodies (DLB) is the second most common cause of neurodegenerative dementia in older people, accounting for 10–15% of all cases. It occupies part of a spectrum thatExpand
SPECT/PET Findings in Dementia with Lewy Bodies
TLDR
This chapter will give an overview of the contribution of PET and SPECT imaging modalities to the diagnosis of DLB and the better understanding of the underlying pathology. Expand
Dementia with Lewy bodies.
The objective was to summarize recent findings about the clinical features, diagnosis and investigation of dementia with Lewy (DLB) bodies, together with its neuropathology, neurochemistry andExpand
Clinical aspects of dementia with Lewy bodies.
  • I. McKeith
  • Psychology, Medicine
  • Handbook of clinical neurology
  • 2008
TLDR
This chapter emphasizes that dementia with Lewy bodies (DLB) is a common disorder, accounting for 10–20% of all cases of dementia, and there is considerable debate as to the relationship between DLB and dementia occurring as a late manifestation of Parkinson's disease (PDD). Expand
Clinical imaging in dementia with Lewy bodies
TLDR
There are suggestions that MIBG may be better in the differentiation of vascular parkinsonism from DLB than DAT scans but may have lower sensitivity for detecting DLB compared with the 80% sensitivity seen in DAT imaging. Expand
Can we clinically diagnose dementia with Lewy bodies yet?
TLDR
A number of studies now suggest that a combination of cellular pathologies, which include α-synuclein and β-amyloid deposition as well as dopamine denervation, assist with differentiating this dementia syndrome from others. Expand
Dopamine transporter imaging for the diagnosis of dementia with Lewy bodies.
TLDR
The aim of this review was to estimate the accuracy of DAT imaging for the diagnosis of DLB in people with dementia in secondary care (specialist dementia services), and to calculate sensitivities, specificities, and their 95% confidence intervals. Expand
Magnetic Resonance Spectroscopy in the Diagnosis of Dementia with Lewy Bodies
TLDR
Proton magnetic resonance spectroscopy (1H-MRS) provides a noninvasive method of assessing an in vivo biochemistry of brain tissue and seems to be a promising method in differential diagnosis of dementia studies. Expand
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References

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Dementia with Lewy bodies.
The objective was to summarize recent findings about the clinical features, diagnosis and investigation of dementia with Lewy (DLB) bodies, together with its neuropathology, neurochemistry andExpand
Research evaluation and prospective diagnosis of dementia with Lewy bodies.
TLDR
It is believed that current criteria for DLBs are useful when DLBs occur in isolation, but have low sensitivity when Lewy bodies coexist with the pathological abnormalities of Alzheimer disease. Expand
Dementia with Lewy bodies
TLDR
This preliminary study identifies components of the evolving clinical and pathologic criteria for DLB that require further refinement that may benefit from further refinement. Expand
Visual hallucinations in Lewy body disease relate to Lewy bodies in the temporal lobe.
TLDR
Cognitive fluctuations and/or visual hallucinations were not good predictors of DLB in pathologically proven patients, although the absence of these features early in the disease course was highly predictive of PDD. Expand
Report of the second dementia with Lewy body international workshop
TLDR
The second International Workshop of the Consortium on Dementia with Lewy Bodies met to review developments since publication of consensus guidelines for the clinical and pathologic diagnosis of DLB, recommending that the clinical consensus criteria be used in their current format. Expand
Pharmacotherapy of dementia with Lewy bodies
TLDR
As the diagnostic criteria for DLB become more refined and validated by postmortem studies, it is hoped that rigorous, well-designed trials will be performed, aimed at alleviating the primary target symptoms of dementia, psychosis and Parkinsonism. Expand
Benefit-Risk Considerations in the Treatment of Dementia with Lewy Bodies
TLDR
It is concluded that patients with DLB may respond better to cholinesterase inhibitors than patients with Alzheimer’s disease on both cognitive and behavioural measures and physicians should exhibit caution when prescribing these agents because of the increased risk of extrapyramidal adverse effects. Expand
Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson’s disease
TLDR
CLBs detected by α-synuclein antibodies in patients with PD are a more sensitive and specific correlate of dementia than the presence of Alzheimer’s pathology, which was present in a minority of the cases in this series. Expand
Dopamine transporter loss visualized with FP-CIT SPECT in the differential diagnosis of dementia with Lewy bodies.
TLDR
Dopamine transporter loss can be detected in vivo using FP-CIT SPECT in DLB and both region of interest analysis and visual ratings provided good separation between DLBs and AD. Expand
Dementia with Lewy bodies
TLDR
This issue of Neurology addresses concerns about clinical diagnostic accuracy and questions whether concomitant neurofibrillary changes of AD influence the clinical presentation of many DLB cases. Expand
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