Diagnosis and management of ANCA associated vasculitis

@article{Berden2012DiagnosisAM,
  title={Diagnosis and management of ANCA associated vasculitis},
  author={Annelies E. Berden and Arda G{\"o}çeroğlu and David R. W. Jayne and Raashid A Luqmani and Niels Rasmussen and Jan A. Bruijn and Ingeborg M. Bajema},
  journal={BMJ : British Medical Journal},
  year={2012},
  volume={344}
}
#### Summary points Vasculitides associated with antineutrophil cytoplasmic antibodies (ANCAs) are systemic autoimmune diseases of unknown cause that affect small to medium sized blood vessels. They include granulomatosis with polyangiitis (formerly Wegener’s granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (formerly Churg-Strauss syndrome). This review mainly focuses on granulomatosis with polyangiitis and microscopic polyangiitis. Although they are… 
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105 Citations
Highly Influential Citations
5
Background Citations
36
Methods Citations
1
Results Citations
1

105 Citations

Biological drugs in ANCA-associated vasculitis.
Granuloma in ANCA-Associated Vasculitides: Another Reason to Distinguish Between Syndromes?
TLDR
It is hypothesized that, as for ANCA, necrotizing granulomatous inflammation and its clinical manifestations are discriminators, assisting subclassification of AAV and/or GPA subphenotypes which will be useful both for designing clinical trials and for treating patients successfully.
Granulomatosis with polyangiitis: update and key concepts
TLDR
Key aspects of granulomatosis with polyangiitis are reviewed, including aspects such as epidemiology, pathophysiology, clinical manifestations, diagnosis and treatment, which are fundamental to the development of new therapies for disease management.
Can genetic studies predict treatment response in antineutrophil cytoplasmic antibody‐associated vasculitis?
  • M. Harigai
  • Biology, Medicine
    International journal of rheumatic diseases
  • 2019
TLDR
Genetic markers of AAV have been extensively studied using both genome-wide and candidate-gene approaches, and are providing clues for better understanding the pathogenesis of A AV and for developing targeted therapies.
Early interstitial lung disease in microscopic polyangiitis: Case report and literature review.
ANCA-associated vasculitis and malignancy: current evidence for cause and consequence relationships.
The Diagnosing Challenge of a Positive ANCA Vasculitis in the Paediatric Age
TLDR
A female teenager presented with a history of subglottic stenosis diagnosed at the age of 12 and a presumptive diagnosis of ANCA-positive vasculitis was made, and she was started corticotherapy, cyclophosphamide, and plasmapheresis.
Clinically-Irrelevant Positivity for Serum Proteinase 3-ANCA in HIV Disease
TLDR
Although ANCA detection may be helpful in diagnosing small-vessel vasculitis in the appropriate clinical scenario, screening for HIV infection should sometimes be considered to discriminate clinically irrelevant serum ANCA positivity.
Propylthiouracil-induced anti-neutrophil cytoplasmic antibody-associated vasculitis mimicking Kawasaki disease
TLDR
This case demonstrates that children with PTU-associated AAV may present with clinical features mimicking Kawasaki disease, and that IVIG along with corticosteroid therapy may be effective in treating patients with drug-induced severe systemic AAV.
ANCA-Associated Vasculitis—ENT Involvement
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are idiopathic, immunologically mediated diseases predominantly affecting small vessels throughout the body (capillaries,…
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References

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TLDR
Patients with ANCA-associated vasculitis treated with conventional regimens are at increased risk of death compared with an age- and sex-matched population.
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TLDR
In patients with generalized vasculitis, the withdrawal of cyclophosphamide and the substitution of azathioprine after remission did not increase the rate of relapse, suggesting the duration of exposure to cycloph phosphamide may be safely reduced.
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TLDR
Investigation of prognostic value of clinical, laboratory, and pathologic features at the time of presentation on patient and renal survival in patients with antineutrophil cytoplasmic autoantibody (ANCA)-associated microscopic polyangiitis and glomerulonephritis found pathology indices such as glomerular necrosis, glomersular crescents,glomerular sclerosis, and interstitial sclerosis were not predictive of renal survival.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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