Diagnosis and Treatment of Childhood Migraine

@article{Merison2016DiagnosisAT,
  title={Diagnosis and Treatment of Childhood Migraine},
  author={Kelsey Merison and Howard S Jacobs},
  journal={Current Treatment Options in Neurology},
  year={2016},
  volume={18},
  pages={1-17}
}
Opinion statementWhile the diagnosis of migraine in children is generally straightforward, treatment can seem complex with a number of medication choices, many of which are used “off label.” Patients with intermittent migraines can often be managed with ibuprofen or naproxen taken as needed. Unfortunately, by the time that children present to our practice, they have often tried these medications without improvement. Triptans are frequently prescribed to these patients with good success. It is… Expand
How to treat children with headache
TLDR
It seems that children with migraine and tensiontype headache have more sleep disturbances than the general population and that sleep difficulties are significantly associated with a high level of dysfunction, anxiety, and depression, which are often comorbidity factors in children’s migraine. Expand
Pharmacological Treatment of Headache and Comorbidities
TLDR
This chapter describes the pharmacotherapy of primary headaches in children affected by additional diseases and summarizes pharmacologic options for migraine and tension-type headache treatment with specific attention to comorbidities. Expand
The efficacy and safety of levetiracetam in the prophylaxis of migraine headaches in children – a randomised trial
TLDR
Results indicate that levetiracetam might be effective and safe in the prophylaxis of migraine headaches in children, and its headache disability score was significantly improved at the end of the trial. Expand
The use of anti-epileptic drugs in prevention of migraine in children and adolescents
TLDR
Sodium valproate was extremely effective in the reduction of migraine frequency in some of the authors' cases, and cinnarizine could be considered as a new preventive option especially for long-term treatment of pediatric migraine, particularly in females. Expand
Current perspectives on the development and treatment of chronic daily headache in children and adolescents.
TLDR
A focused review on recent empirical work done on pediatric CDH and suggest avenues for future work are suggested. Expand
Antihypertensive agents: a long way to safe drug prescribing in children
TLDR
Several gaps were noted in the literature, particularly for beta blockers, vasodilators, and the long-term safety profile of antihypertensive agents in children, and further clinical trials are needed to guide safe and effective prescribing in the pediatric population. Expand
Evaluation and Treatment of Primary Headaches in Adolescents.
TLDR
Evaluation of headaches in primary care requires a comprehensive assessment including lifestyle behaviors and physical examination, as well as an understanding of when to pursue appropriate testing. Expand
Headache in Autism Spectrum Disorders
TLDR
Headache and related disorders may affect children with ASD as an additional problem to keep in mind when evaluating pain of uncertain origin in this vulnerable population. Expand
A retrospective analysis of triptan and dhe use for basilar and hemiplegic migraine
TLDR
The objective of this study was to demonstrate that triptans and DHE can be used for the abortive treatment of BM and HM without significant adverse ischemic vascular events. Expand
Repurposed drug candidates for antituberculosis therapy.
TLDR
Progress in the discovery of new anti-TB agents through drug repurposing since 2014 is discussed, and the challenges faced are discussed and the innovative ways that are being used to overcome these difficulties are analyzed. Expand
...
1
2
...

References

SHOWING 1-10 OF 79 REFERENCES
Treatment of Pediatric Migraine
TLDR
Rescue medication including dihydroergotamine (DHE), a potent vasoconstrictor should be used for intractable migraines and is preferred in the hospital setting. Expand
Non‐Steroidal Anti‐Inflammatories for the Acute Treatment of Migraine
TLDR
Menstrual migraine is one of the most challenging forms of migraine, and NSAIDS, especially when added to a triptan, will attack both pain pathways so that inflammation as well as blood vessel dilation are suppressed. Expand
Ibuprofen or Acetaminophen for the Acute Treatment of Migraine in Children
TLDR
Both ib uprofen and acetaminophen are effective and economical treatments for severe or moderate migraine attacks in children and Ibuprofen gave the best relief. Expand
Predictors of Triptan Response in Pediatric Migraine.
TLDR
In contrast to what has been documented in adults, cranial autonomic symptoms and aura did not predict triptan response, although the small sample size limited the study's power. Expand
Prochlorperazine in children with migraine: a look at its effectiveness and rate of akathisia.
TLDR
Prochlorperazine seems very effective to decrease pain on a short-term basis in children with severe migraine, but more than two thirds of the patients, overall, had a relapse of their migraine at home in the first week of discharge, despite the use of diphenhydramine. Expand
Efficacy and tolerability of rizatriptan in pediatric migraineurs: Results from a randomized, double-blind, placebo-controlled trial using a novel adaptive enrichment design
TLDR
Rizatriptan demonstrated a statistically significant improvement over placebo in eliminating pain and was generally well tolerated in migraineurs aged 12–17 and 6–17 years. Expand
Migraine variants – Occurrence in pediatric neurology practice
TLDR
Basilar type migraine was the most common migraine variant and ACM and AWS should be regarded as distinct entities in the ICHD as migraine with complex aura. Expand
A Randomized Trial of Propranolol versus Sodium Valproate for the Prophylaxis of Migraine in Pediatric Patients
TLDR
This prospective study supports the efficacy of propranolol and sodium valproate as prophylaxis for pediatric migraine without aura, based on IHS criteria. Expand
Primary Headaches in Children: Clinical Findings and the Association with other Conditions
TLDR
Primary headaches in children are not associated with most of the psychiatric and systemic conditions herein investigated, but there was a significant association with anxiety and depression, as frequently reported in adults. Expand
Increased RLS prevalence in children and adolescents with migraine: A case-control study
TLDR
This is the first study suggesting an association between RLS and migraine in the pediatric population and future studies are needed to determine the extent of sleep disruption in children and adolescents with migraine and comorbid RLS. Expand
...
1
2
3
4
5
...