Diagnosis and Treatment of Childhood Acute Lymphoblastic Leukemia

  title={Diagnosis and Treatment of Childhood Acute Lymphoblastic Leukemia},
  author={Dario Campana and Ching-Hon Pui},
Leukemia is the most common pediatric cancer. Acute lymphoblastic leukemia (ALL) is the most prevalent subtype, accounting for 75–80 % of all cases. Leukemias arise from genetic changes that occur in a single progenitor cell at various stages of maturation, resulting in a clonal expansion. The single-cell origin of ALL is demonstrated clearly by the finding of clonal rearrangements of T-cell receptor (TCR) or immunoglobulin genes [1]. ALL cells reflect, at least in part, the immunophenotypic… CONTINUE READING