Diagnosis and Treatment Patterns in Celiac Disease

@article{Cichewicz2019DiagnosisAT,
  title={Diagnosis and Treatment Patterns in Celiac Disease},
  author={Allie Cichewicz and Elizabeth S Mearns and Aliki Taylor and Talia Boulanger and Michele Gerber and Daniel A. Leffler and Jennifer Drahos and David S. Sanders and Kelly J. Thomas Craig and Benjamin Lebwohl},
  journal={Digestive Diseases and Sciences},
  year={2019},
  volume={64},
  pages={2095-2106}
}
Celiac disease (CD) is an immune-mediated gastrointestinal (GI) disorder driven by innate and adaptive immune responses to gluten. Presentation of CD has changed over time, with non-GI symptoms, such as anemia and osteoporosis, presenting more commonly. With improved screening and diagnostic methods, the reported prevalence of CD has increased globally, and there is considerable global variation in diagnostic and treatment practices. The objective of this study was to describe the current state… Expand
Optimization of serologic diagnosis of celiac disease in the pediatric setting.
TLDR
The use of the ESPGHAN non-biopsy approach could reduce small bowel biopsies, but thresholds for IgA-tTG levels are not aligned across assays and should be based on predefined likelihood ratios or specificity. Expand
Update on celiac disease
  • M. Alkalay
  • Medicine
  • Current opinion in pediatrics
  • 2020
TLDR
The authors' knowledge of celiac disease continues to grow with increasing evidence of contributory factors to its pathogenesis, and current therapeutic trials offer promising nondietary treatment for celiac patients. Expand
Non-Invasive Biomarkers for Celiac Disease
TLDR
In the present review, the pros and cons of available biomarkers are discussed comprehensively, the current status of emerging biomarkers for the screening, diagnosis, and monitoring of celiac disease are summarized, and the capability of prediction of enteropathy by the presence of the high titer of anti-tissue transglutaminase antibody is summarized. Expand
Celiac disease: uncommon, oligosymptomatic course of illness, with profound hypoalbuminemia in an adult patient
TLDR
A rare case of a patient, who’s first and practically the only symptom of the disease was a pathological fracture of the ribs, is presented, which suggests that CD diagnostic should be undertaken in evaluation of every patient with osteoporotic fractures and hypoalbuminemia. Expand
Celiac Disease, Gluten-Free Diet, and Metabolic and Liver Disorders
TLDR
Investigation of the links between a gluten-free diet (GFD) and metabolic/liver disorders in CD patients found increases in the frequency of NAFLD, weight gain, and alterations of the lipid profile suggest that important changes happen in celiac patients on a GFD, though the physiopathology of these conditions is unclear. Expand
Society for the Study of Celiac Disease position statement on gaps and opportunities in coeliac disease
TLDR
This Roadmap summarizes key advances in coeliac disease and provides recommendations from a consensus workshop to address the gaps and opportunities in the pathogenesis, diagnosis and management of coeliak disease, providing a path forward. Expand
Gastrointestinal motility and absorptive disorders in patients with inflammatory bowel diseases: Prevalence, diagnosis and treatment
TLDR
The prevalence, diagnosis and treatment of GI motility and absorptive disorders that commonly affect patients with IBD are described. Expand
General Health, Systemic Diseases and Oral Status in Adult Patients with Coeliac Disease
TLDR
Major associations were observed in caries prevalence and dentin sensitivity; in addition, an inappropriate diet was related to oral manifestations; following a gluten-free diet could be important to control the gingival bleeding levels and to manage oral symptoms associated to coeliac disease. Expand
Celiac Disease: A Common Unrecognized Health Problem with a Very Delayed Diagnosis
Celiac disease (CD) is a clinical entity of autoimmune nature, related to the presence of a permanent gluten intolerance that affects genetically predisposed individuals, producing a chronicExpand
Nutritional Imbalances in Adult Celiac Patients Following a Gluten-Free Diet
TLDR
The nutritional imbalances which may be found in adults with CD following a GFD are described, which are related to the consumption of GFP and their nutritional composition, in addition to unbalanced dietary habits. Expand
...
1
2
...

References

SHOWING 1-10 OF 145 REFERENCES
ACG Clinical Guidelines: Diagnosis and Management of Celiac Disease
TLDR
Given the incomplete response of many patients to a GFD-free diet as well as the difficulty of adherence to the GFD over the long term, development of new effective therapies for symptom control and reversal of inflammation and organ damage are needed. Expand
The present and the future in the diagnosis and management of celiac disease
TLDR
Alternative therapies—including gluten modification, modulation of intestinal permeability and immune response—could be central to the future treatment of celiac disease. Expand
Diagnostic challenges in celiac disease.
TLDR
Persistence or recurrence of symptoms, despite the ongoing treatment, requires a revision of the initial diagnosis, an evaluation of the gluten free diet and a search for concurrent disorders or complications. Expand
Celiac disease.
TLDR
The development of serologic markers specific to CD has revolutionized the ability both to diagnose and monitor patients with the disease, and the extent of other environmental factors in the pathogenesis of the disease is an area of continued research. Expand
Celiac disease: a clinical review
TLDR
The majority of patients will respond to a lifelong gluten-free diet which is the cornerstone of therapy, and complications such as refractory CD, ulcerative jejunoileitis, enteropathy associated T-cell lymphoma and small bowel adenocarcinoma occur in a minority of patients. Expand
Coeliac disease: review of diagnosis and management
TLDR
Diagnosis of coeliac disease is important to prevent nutritional deficiency and long term risk of gastrointestinal malignancy, and adherence to a gluten free diet allows duodenal mucosal healing and alleviates symptoms. Expand
Celiac disease: a review.
TLDR
Diagnosing celiac disease requires a high degree of suspicion, followed by correct screening and a confirmatory test with an intestinal biopsy, which in most cases will bring a marked improvement of symptoms. Expand
Coeliac disease
TLDR
The Marsh classification of intestinal coeliac lesions, as modified by Oberhuber et al, is used by most pathologists to evaluate the intestinal lesions of patients with CD, both for diagnosis and to assess the regression of the lesions after a gluten free diet. Expand
The spectrum of celiac disease: epidemiology, clinical aspects and treatment
TLDR
A strict life-long gluten-free diet is the only safe and efficient available treatment, yet it results in a social burden and alternative treatment modalities focus on modification of dietary components, enzymatic degradation of gluten, inhibition of intestinal permeability and modulation of the immune response. Expand
Etiologies and predictors of diagnosis in nonresponsive celiac disease.
TLDR
Weight loss and male sex were highly predictive of refractory CD and a limited number of etiologies account for the majority of cases, which is a common phenomenon affecting 10%-19% of celiac patients. Expand
...
1
2
3
4
5
...