Diagnosis and Treatment Patterns in Celiac Disease

  title={Diagnosis and Treatment Patterns in Celiac Disease},
  author={Allie Cichewicz and Elizabeth S Mearns and Aliki Taylor and Talia Boulanger and Michele Gerber and Daniel A. Leffler and Jennifer Drahos and David S. Sanders and Kelly Jean Thomas Craig and Benjamin Lebwohl},
  journal={Digestive Diseases and Sciences},
Celiac disease (CD) is an immune-mediated gastrointestinal (GI) disorder driven by innate and adaptive immune responses to gluten. Presentation of CD has changed over time, with non-GI symptoms, such as anemia and osteoporosis, presenting more commonly. With improved screening and diagnostic methods, the reported prevalence of CD has increased globally, and there is considerable global variation in diagnostic and treatment practices. The objective of this study was to describe the current state… 
Editorial commentary on the Indian Journal of Gastroenterology—January–February 2022
  • J. Limdi
  • Medicine
    Indian Journal of Gastroenterology
  • 2022
Among unmet needs for CD, physician awareness of diagnostic criteria, improved access to specialist assessment, and the impact of education about gluten-free eating as well as access and availability of gluten- free foods to support adherence need further study.
Non-Invasive Biomarkers for Celiac Disease
In the present review, the pros and cons of available biomarkers are discussed comprehensively, the current status of emerging biomarkers for the screening, diagnosis, and monitoring of celiac disease are summarized, and the capability of prediction of enteropathy by the presence of the high titer of anti-tissue transglutaminase antibody is summarized.
Celiac disease: uncommon, oligosymptomatic course of illness, with profound hypoalbuminemia in an adult patient
A rare case of a patient, who’s first and practically the only symptom of the disease was a pathological fracture of the ribs, is presented, suggesting that CD diagnostic should be undertaken in evaluation of every patient with osteoporotic fractures and hypoalbuminemia.
Celiac Disease, Gluten-Free Diet, and Metabolic and Liver Disorders
Investigation of the links between a gluten-free diet (GFD) and metabolic/liver disorders in CD patients found increases in the frequency of NAFLD, weight gain, and alterations of the lipid profile suggest that important changes happen in celiac patients on a GFD, though the physiopathology of these conditions is unclear.
Biochemical abnormalities among patients referred for celiac disease antibody blood testing in a primary health care setting
The pattern of abnormalities suggested that micronutrient deficiencies were prevalent among CD antibody-positive individuals, confirming malabsorption as a sign of CD.
Gallstone Frequency in Adults With Celiac Disease: Results of a Population-Based Celiac Disease Registry From West Azerbaijan, IRAN
A significant relationship was found between the frequency of gallstones and bilirubin levels in patients with CD, suggesting the prevalence of biliary stones in celiac patients may be higher compared to the normal population.
Celiac Disease: A Common Unrecognized Health Problem with a Very Delayed Diagnosis
Celiac disease (CD) is a clinical entity of autoimmune nature, related to the presence of a permanent gluten intolerance that affects genetically predisposed individuals, producing a chronic
Nutritional Imbalances in Adult Celiac Patients Following a Gluten-Free Diet
The nutritional imbalances which may be found in adults with CD following a GFD are described, which are related to the consumption of GFP and their nutritional composition, in addition to unbalanced dietary habits.
Multidimensional Disadvantages of a Gluten-Free Diet in Celiac Disease: A Narrative Review
An adequate nutritional counselling is necessary for patients diagnosed with celiac disease in order to prevent and treat the components of the metabolic syndrome.


ACG Clinical Guidelines: Diagnosis and Management of Celiac Disease
Given the incomplete response of many patients to a GFD-free diet as well as the difficulty of adherence to the GFD over the long term, development of new effective therapies for symptom control and reversal of inflammation and organ damage are needed.
The present and the future in the diagnosis and management of celiac disease
Alternative therapies—including gluten modification, modulation of intestinal permeability and immune response—could be central to the future treatment of celiac disease.
Diagnostic challenges in celiac disease.
Persistence or recurrence of symptoms, despite the ongoing treatment, requires a revision of the initial diagnosis, an evaluation of the gluten free diet and a search for concurrent disorders or complications.
Celiac disease.
Celiac disease: a clinical review
The majority of patients will respond to a lifelong gluten-free diet which is the cornerstone of therapy, and complications such as refractory CD, ulcerative jejunoileitis, enteropathy associated T-cell lymphoma and small bowel adenocarcinoma occur in a minority of patients.
Coeliac disease
The Marsh classification of intestinal coeliac lesions, as modified by Oberhuber et al, is used by most pathologists to evaluate the intestinal lesions of patients with CD, both for diagnosis and to assess the regression of the lesions after a gluten free diet.
Celiac disease: a review.
Diagnosing celiac disease requires a high degree of suspicion, followed by correct screening and a confirmatory test with an intestinal biopsy, which in most cases will bring a marked improvement of symptoms.
The spectrum of celiac disease: epidemiology, clinical aspects and treatment
A strict life-long gluten-free diet is the only safe and efficient available treatment, yet it results in a social burden and alternative treatment modalities focus on modification of dietary components, enzymatic degradation of gluten, inhibition of intestinal permeability and modulation of the immune response.
Etiologies and predictors of diagnosis in nonresponsive celiac disease.