Diagnosis and Management of Acute Myelopathies

@article{Kaplin2005DiagnosisAM,
  title={Diagnosis and Management of Acute Myelopathies},
  author={Adam I. Kaplin and Chitra Krishnan and Deepa M. Deshpande and Carlos A. Pardo and Douglas A. Kerr},
  journal={The Neurologist},
  year={2005},
  volume={11},
  pages={2-18}
}
Background:Acute myelopathies represent a heterogeneous group of disorders with distinct etiologies, clinical and radiologic features, and prognoses. Transverse myelitis (TM) is a prototype member of this group in which an immune-mediated process causes neural injury to the spinal cord, resulting in varying degrees of weakness, sensory alterations, and autonomic dysfunction. TM may exist as part of a multifocal CNS disease (eg, MS), multisystemic disease (eg, systemic lupus erythematosus), or… 

Transverse Myelitis: pathogenesis, diagnosis and treatment.

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Evaluation of myelopathies when no abnormalities are seen on spinal cord imaging is a commonly encountered diagnostic challenge and some "clinical pearls" in the evaluation and management of spinal cord diseases are presented.

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Clinical trials testing the efficacy of promising axonoprotective agents in combination with intravenous steroids in the treatment of TM are currently underway, as the levels of interleukin-6 in the cerebrospinal fluid of acute TM patients strongly correlate with and are highly predictive of disability.

Initial presentation of acute transverse myelitis in systemic lupus erythematosus: demographics, diagnosis, management and comparison to idiopathic cases

The diagnosis, demographics and management of systemic lupus erythematosus (SLE) related versus idiopathic acute transverse myelitis during the initial presentation of the disease underlines the importance of early diagnosis of patients who develop ATM related to SLE.

Post-infectious Acute Transverse Myelitis

Prognosis for children with post-infectious acute TM is quite variable, while the majority of children do have full or good recovery, many are left with residual neurologic deficits including persistent ambulatory difficulties, sensory disturbances, and/or abnormal bladder function.
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