Diagnosis and Drug Therapy of Prolactinoma

@article{Ciccarelli1996DiagnosisAD,
  title={Diagnosis and Drug Therapy of Prolactinoma},
  author={Enrica Ciccarelli and Franco Camanni},
  journal={Drugs},
  year={1996},
  volume={51},
  pages={954-965}
}
SummaryA prolactin-secreting pituitary tumour is the most frequent cause of hyperprolactinaemia that commonly occurs in clinical practice. Prolactinomas occur more frequently in women than in men and may differ in size, invasive growth and secretory activity. At presentation, macroadenomas are more frequently diagnosed in men. Specific immunohistochemical stains are necessary to prove the presence of prolactin in the tumour cells. The main investigations in the diagnosis of a prolactin… 

Pituitary Disorders

Pituitary diseases are relatively common entities in the general population. They include pituitary adenomas and hypopituitarism. Pituitary tumours can cause symptoms of mass effect and hormonal

Managing prolactinoma during pregnancy

Objective: Prolactinomas are the most common pituitary tumors in pregnant women. We conducted this study on pregnant women with prolactinoma to determine their clinical symptoms and signs and

Italian Association of Clinical Endocrinologists (AME) and International Chapter of Clinical Endocrinology (ICCE). Position statement for clinical practice: prolactin-secreting tumors

The impressive improvement of neurosurgical endoscopic techniques allows a far better definition of the tumoral tissue during surgery and the remission of endocrine symptoms in many patients with pituitary tumors, changing the therapeutic strategy in prolactinomas.

MRI brain findings in patients with high serum prolactin levels

Most of Patients had an abnormal MRI finding, showing that MRI screening should berecommended for Prolactin levels above 1000mIU/L, and microadenoma was the most common abnormality, having higher incidence in female patients.

Managing Prolactinoma during Pregnancy Prolactinoma during Pregnancy Prolactinoma during Pregnancy Prolactinoma during Pregnancy

Macroprolactinomas are more likely to enlarge during pregnancy than microprolActinomas, and conservative management was successfully done in all patients without surgery or medical therapy.

Clinical management and outcome of 36 invasive prolactinomas treated with dopamine agonist

Patients who achieve TVR >25% with NP with 3 months of bromocriptine administration had a high possibility of showing good long-term response (TVR >50% withNP) to bromoriptine, and a higher dose of dopamine agonist (DA) or other DA should be considered for patients who achieveTVR <25% without NP.

Clinical Outcome of Invasive Pituitary Prolactinomas Treated with Cabergoline

Patients who achieve TVRˁ25%with NP with 3 months of cabergoline administration had a high possibility of showing good long term response (TVR˃50% with NP) to cabergol, and a higher dose of dopamine agonist (DA) should be considered for patients who achieve televisionR˂25% without NP.

Chapter 29 Multimodality Treatment of Pituitary Adenomas

The mortality in untreated acromegaly is two to three times higher than that of the general population, but with appropriate reduction of GH hypersecretion, it normalizes.

Pregnancy and pituitary disorders.

The changes in anatomy and physiology of the pituitary gland during pregnancy are reviewed and Pituitary disorders namely Cushing's disease; acromegaly; prolactinoma; TSH-secreting, gonadotropin-producing, and clinically nonfunctioning adenomas; craniopharyngioma; and Sheehan's syndrome in relation to pregnancy are discussed.

Efficacy of cabergoline on rapid escalation of dose in men with macroprolactinomas.

The preliminary findings show that rapid build-up of cabergoline doses increases its efficacy as well as rapidity of response in terms clinical improvement, normalization of serum prolactin and gonadal functions and reduction in tumour size, without compromising its safety in men with macroprolactinomas.

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