Diagnosing small bowel malabsorption: a review

  title={Diagnosing small bowel malabsorption: a review},
  author={Cinzia Papadia and Antonio Di Sabatino and Gino Roberto Corazza and Alastair Forbes},
  journal={Internal and Emergency Medicine},
Malabsorption encompasses dysfunctions occurring during the digestion and absorption of nutrients. A small proportion of patients presents with chronic diarrhoea. A clinical history supportive of malabsorption may guide investigations toward either the small bowel or pancreas. Serological testing for coeliac disease will determine most cases without invasive investigations. In the clinical context of persisting weight loss and malnutrition, small bowel enteropathy may be investigated with small… 

Diagnosing small bowel malabsorption

  • D. Vaira
  • Medicine
    Internal and Emergency Medicine
  • 2013
The review article published in the present issue of Intern Emerg Med, from Corazza’s group [1], is an in-depth description of the up-to-date clinical features of small bowel malabsorption, but at

Disorders associated with malabsorption of iron: A critical review

Using the index terms malabsorption, postgastrectomy, chronic pancreatitis, pancreatic cancer, cystic fibrosis, gallstones, cholangitis, celiac disease, tropical sprue, Crohn’s disease intestinal lymphangiectasia, macroglobulinemia and iron deficiency anemia the MEDLINE and EMBASE databases were searched.

Citrulline as marker of atrophy in celiac disease

A prospective study to evaluate whether the serum CIT level might be included in a practical diagnostic work up of subjects with suggestive symptoms for CD, and the experience with the CITlevel in subjects highly suspected for CD.

Gastrointestinal failure in the ICU

A systematic approach to management of gastrointestinal problems is recommended and possible pathophysiological mechanisms and different aspects in assessment of gastrointestinal function in adult ICU patients are presented.

Coeliac disease: an old or a new disease? History of a pathology

Whether the incidence of the celiac disease is actually increased or if has been considered less frequent for the lower valuation of the signs once deemed more atypical, but currently considered preliminary indicative of the pathology is investigated.

Testing for Chronic Diarrhea.

  • M. Raman
  • Medicine
    Advances in clinical chemistry
  • 2017

A novel method to identify fat malabsorption: the Serum Retinyl Palmitate Test.

Effect of Teduglutide, a Glucagon-like Peptide 2 Analog, on Citrulline Levels in Patients With Short Bowel Syndrome in Two Phase III Randomized Trials

Teduglutide treatment was associated with reductions from baseline in PS (parenteral support) volume requirements; however, a significant correlation between PS reduction and increase in plasma citrulline at Week 24 was observed in only one out of the three tedugliltide treatment groups.

The Microbiome, Intestinal Function, and Arginine Metabolism of Healthy Indian Women Are Different from Those of American and Jamaican Women.

It is suggested that dysregulated intestinal function and a unique gut microbiome may contribute to altered arginine metabolism in Indian women.



Diagnosing malabsorption in the intensive care unit

A citrulline generation test was recently developed in order to measure the conversion of glutamine (administered either enterally or intravenously), which may be a promising biomarker for assessment of the small bowel function.

Is serum citrulline measurement clinically useful in coeliac disease?

Although, as expected, serum citrulline levels turned out to be low in coeliac disease, the clinical utility of their measurement is, at least, questionable in this condition.

Plasma Citrulline Concentration: A Reliable Marker of Small Bowel Absorptive Capacity Independent of Intestinal Inflammation

Plasma citrulline concentration is a simple and reliable surrogate for small bowel absorptive capacity and is not influenced by intestinal inflammation.

Duodenal Pathology and Clinical-Immunological Implications in Common Variable Immunodeficiency Patients

Duodenal villous atrophy is very frequent in symptomatic CVID patients, with relevant clinical and immunological implications, and is significantly associated with anemia, malnutrition, and low blood CD4+ lymphocyte levels.

Coeliac disease

The Marsh classification of intestinal coeliac lesions, as modified by Oberhuber et al, is used by most pathologists to evaluate the intestinal lesions of patients with CD, both for diagnosis and to assess the regression of the lesions after a gluten free diet.

The Enteropathy Associated With Common Variable Immunodeficiency: The Delineated Frontiers With Celiac Disease

Several distinctive features differentiate CVID enteropathy from other causes of enteropathy including CS, and replacement i.v. Ig therapy is insufficient to improve gastrointestinal symptoms.

Small intestinal permeability in normal Sudanese subjects: evidence of tropical enteropathy.

Limitations of the triolein breath test.