Diagnosing prion diseases: needs, challenges and hopes

Abstract

Prion diseases are among the most intriguing infectious diseases and are associated with unconventional proteinaceous infectious agents known as prions. Prions seem to lack nucleic acid and propagate by transmission of protein misfolding. The nature of prions and their unique mode of transmission present challenges for early diagnosis of prion diseases. In… (More)
DOI: 10.1038/nrmicro1003

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