Diagnosing nonimmediate reactions to penicillins by in vivo tests.

  title={Diagnosing nonimmediate reactions to penicillins by in vivo tests.},
  author={Antonio Romano and Marinella Viola and Chiara Mondino and Rosa Pettinato and Maina Di Fonso and Giuseppe Papa and Alberto Venuti and Paolo Montuschi},
  journal={International archives of allergy and immunology},
  volume={129 2},
BACKGROUND Maculopapular and urticarial rashes are nonimmediate manifestations common during penicillin treatment; the former often represent cell-mediated hypersensitivity. Our objectives were to assess the incidence of allergy in adults reporting nonimmediate manifestations during penicillin therapy and to evaluate the diagnostic potential of patch tests, delayed-reading skin tests and challenges in such cases. METHODS We used prick and intradermal tests as well as patch tests with… CONTINUE READING