Diagnosing Schistosomiasis by Detection of Cell-Free Parasite DNA in Human Plasma

  title={Diagnosing Schistosomiasis by Detection of Cell-Free Parasite DNA in Human Plasma},
  author={Dominic Wichmann and Marcus Panning and Thomas Quack and Stefanie Kramme and Gerd Dieter Burchard and Christoph G Grevelding and Christian Drosten},
  journal={PLoS Neglected Tropical Diseases},
  pages={1561 - 1569}
INTRODUCTION Schistosomiasis (bilharzia), one of the most relevant parasitoses of humans, is confirmed by microscopic detection of eggs in stool, urine, or organ biopsies. The sensitivity of these procedures is variable due to fluctuation of egg shedding. Serological tests on the other hand do not distinguish between active and past disease. In patients with acute disease (Katayama syndrome), both serology and direct detection may produce false negative results. To overcome these obstacles, we… CONTINUE READING


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