Diadenosine tetraphosphate induces tight junction disassembly thus increasing corneal epithelial permeability.

@article{Loma2015DiadenosineTI,
  title={Diadenosine tetraphosphate induces tight junction disassembly thus increasing corneal epithelial permeability.},
  author={Patricia Loma and Ana I Guzm{\'a}n-Aranguez and Mar{\'i}a Jes{\'u}s Perez de Lara and Jes{\'u}s Pintor},
  journal={British journal of pharmacology},
  year={2015},
  volume={172 4},
  pages={1045-58}
}
BACKGROUND AND PURPOSE Here, we have studied the effects of the dinucleotide P(1), P(4)-Di (adenosine-5') tetraphosphate (Ap4 A) on corneal barrier function conferred by the tight junction (TJ) proteins and its possible involvement in ocular drug delivery and therapeutic efficiency. EXPERIMENTAL APPROACH Experiments in vitro were performed using human corneal epithelial cells (HCLEs) treated with Ap4 A (100 μM) for 5 min. Western blot analysis and transepithelial electrical resistance (TEER… CONTINUE READING

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