Diadenosine tetraphosphate-gating of recombinant pancreatic ATP-sensitive K(+) channels.

@article{Jovanovi2001DiadenosineTO,
  title={Diadenosine tetraphosphate-gating of recombinant pancreatic ATP-sensitive K(+) channels.},
  author={Sofija Jovanovi{\'c} and Aleksandar Jovanovi{\'c}},
  journal={Bioscience reports},
  year={2001},
  volume={21 1},
  pages={93-9}
}
Diadenosine tetraphosphate (Ap4A) has been recently discovered in the pancreatic beta cells where targets ATP-sensitive K(+) (K(ATP)) channels, depolarizes the cell membrane and induces insulin secretion. However, whether Ap4A inhibit pancreatic K(ATP) channels by targeting protein channel complex itself was unknown. Therefore, we coexpressed pancreatic K(ATP) channel subunits, Kir6.2 and SUR1, in COS-7 cells and examined the effect of Ap4A on the single channel behavior using the inside-out… CONTINUE READING