Diadenosine polyphosphates' action on calcium and vessel contraction.

  title={Diadenosine polyphosphates' action on calcium and vessel contraction.},
  author={Martin Tepel and Joachim Jankowski and Hartmut Schl{\"u}ter and Jean Bachmann and Markus van der Giet and C Ruess and J Terliesner and Walter Zidek},
  journal={American journal of hypertension},
  volume={10 12 Pt 1},
The effects of the endogenous, platelet-derived vasoactive compounds, diadenosine tetraphosphate (AP4A), diadenosine pentaphosphate (AP5A), and diadenosine hexaphosphate (AP6A) on the vasoconstriction of isolated rat renal resistance vessels and rat aortic strips were measured using a vessel myograph. In addition, the effects of AP4A, AP5A, and AP6A on the cytosolic free calcium concentration ([Ca2+]i) were evaluated in cultured rat vascular smooth muscle cells (VSMC) using the fluorescent dye… CONTINUE READING