Diacylglycerol is required for the formation of COPI vesicles in the Golgi-to-ER transport pathway.

@article{FernndezUlibarri2007DiacylglycerolIR,
  title={Diacylglycerol is required for the formation of COPI vesicles in the Golgi-to-ER transport pathway.},
  author={In{\'e}s Fern{\'a}ndez-Ulibarri and Montserrat Vilella and Francisco L{\'a}zaro-Di{\'e}guez and Elisabet Sarri and Susana E Mart{\'i}nez and Nuria Jim{\'e}nez and Enrique Claro and Isabel M{\'e}rida and Koert N. J. Burger and Gustavo Egea},
  journal={Molecular biology of the cell},
  year={2007},
  volume={18 9},
  pages={
          3250-63
        }
}
Diacylglycerol is necessary for trans-Golgi network (TGN) to cell surface transport, but its functional relevance in the early secretory pathway is unclear. Although depletion of diacylglycerol did not affect ER-to-Golgi transport, it led to a redistribution of the KDEL receptor to the Golgi, indicating that Golgi-to-ER transport was perturbed. Electron microscopy revealed an accumulation of COPI-coated membrane profiles close to the Golgi cisternae. Electron tomography showed that the majority… CONTINUE READING
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