Diacylglycerol and phorbol ester stimulate secretion without raising cytoplasmic free calcium in human platelets

@article{Rink1983DiacylglycerolAP,
  title={Diacylglycerol and phorbol ester stimulate secretion without raising cytoplasmic free calcium in human platelets},
  author={Timothy P. Rink and Ana Ureba S{\'a}nchez and Trevor J. Hallam},
  journal={Nature},
  year={1983},
  volume={305},
  pages={317-319}
}
An increase in cytoplasmic free calcium, [Ca2+]i, is thought to be the trigger for secretory exocytosis in many cells1–3. In blood platelets, large rises in [Ca2+]i can cause secretion4,5 and calcium has been regarded as the final common activator not only for secretion but also for shape-change and aggregation6,7. We have shown that while thrombin5 and platelet-activating factor (PAF)8 normally elevate [Ca2+]i, they can also stimulate shape-change and secretion even when the [Ca2+]i rise is… CONTINUE READING
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