Diacylglycerol/protein kinase C signalling: a mechanism for insulin resistance?

  title={Diacylglycerol/protein kinase C signalling: a mechanism for insulin resistance?},
  author={Einat Shmueli and K. George M. M. Alberti and Christopher Oswold Record},
  journal={Journal of internal medicine},
  volume={234 4},
It is proposed that an intracellular cycle exists to limit or terminate the insulin signal. The cycle involves increased synthesis of sn-1,2-diacylglycerol (DAG) in response to insulin. The DAG activates protein kinase C (PKC) which phosphorylates glycogen synthase either directly or through other protein kinases to render it inactive. Protein kinase C may also inhibit the insulin receptor by phosphorylation of receptor serine residues. Insulin resistance could then arise as a consequence of a… CONTINUE READING


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