Diacylglyceride lipase activity in rod outer segments depends on the illumination state of the retina.

@article{Pasquar2008DiacylglycerideLA,
  title={Diacylglyceride lipase activity in rod outer segments depends on the illumination state of the retina.},
  author={Susana J. Pasquar{\'e} and Norma Mar{\'i}a Giusto},
  journal={Neurochemistry international},
  year={2008},
  volume={53 6-8},
  pages={382-8}
}
We have demonstrated that the competition between phosphatidic acid (PA) and lysophosphatidic acid (LPA), sphingosine 1-phosphate (S1P) and ceramide 1-phosphate (C1P) for lipid phosphate phosphatases (LPP) generates different levels of diacylglycerol (DAG) depending on the illumination state of the retina. The aim of the present research was to determine the diacylglyceride lipase (DAGL) activity in purified rod outer segments (ROS) obtained from dark-adapted retinas (DROS) or light-adapted… CONTINUE READING