Diacylated Sulfoglycolipids Are Novel Mycobacterial Antigens Stimulating CD1-restricted T Cells during Infection with Mycobacterium tuberculosis

@article{Gilleron2004DiacylatedSA,
  title={Diacylated Sulfoglycolipids Are Novel Mycobacterial Antigens Stimulating CD1-restricted T Cells during Infection with Mycobacterium tuberculosis},
  author={Martine Gilleron and Steffen Stenger and Zaima Mazorra and Frederick Wittke and Sabrina Mariotti and Gabriele Boehmer and Jacques Prandi and Lucia Mori and Germain Puzo and Gennaro De Libero},
  journal={The Journal of Experimental Medicine},
  year={2004},
  volume={199},
  pages={649 - 659}
}
Mycobacterial lipids comprise a heterogeneous group of molecules capable of inducing T cell responses in humans. To identify novel antigenic lipids and increase our understanding of lipid-mediated immune responses, we established a panel of T cell clones with different lipid specificities. Using this approach we characterized a novel lipid antigen belonging to the group of diacylated sulfoglycolipids purified from Mycobacterium tuberculosis. The structure of this sulfoglycolipid was identified… CONTINUE READING
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2 Excerpts

Crystal structure of CD 1 a in complex with a sulfatide self antigen at a resolution of 2 . 15 A

  • A. Shamshiev, H. J. Gober, A. Donda, Z. Mazorra, L. Mori, G. De Libero
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