Diacyl glyceryl ester prodrugs for slow release in the skin: synthesis and in vitro degradation and absorption studies for naproxen derivatives.

@article{Thorsteinsson1999DiacylGE,
  title={Diacyl glyceryl ester prodrugs for slow release in the skin: synthesis and in vitro degradation and absorption studies for naproxen derivatives.},
  author={Thorsteinn Thorsteinsson and M{\'a}r M{\'a}sson and Thorsteinn Loftsson and Gudmundur G. Haraldsson and Einar Stef{\'a}nsson},
  journal={Die Pharmazie},
  year={1999},
  volume={54 11},
  pages={831-6}
}
Diacyl glyceryl ester derivatives of naproxen were synthesized and tested for transdermal and dermal administration. Diacyl derivatives of aliphatic acids of various chain length were compared. The pharmaceutical properties of these compounds, such as lipophilicity, hydrolysis in a buffer solution at various pH values and degradation in human serum and… CONTINUE READING