Diacetylated derivatives of spermine and spermidine as novel promising tumor markers.

@article{Kawakita2006DiacetylatedDO,
  title={Diacetylated derivatives of spermine and spermidine as novel promising tumor markers.},
  author={Masao Kawakita and Kyoko Hiramatsu},
  journal={Journal of biochemistry},
  year={2006},
  volume={139 3},
  pages={315-22}
}
N1,N12-diacetylspermine (DiAcSpm) and N1,N8-diacetylspermidine (DiAcSpd) are minor components of human urinary polyamine to which little attention has been paid until recently. HPLC analysis of urinary polyamines has revealed that the excretion of these diacetylpolyamines, in particular, into urine was frequently and markedly increased in association with every type of cancer so far examined. Remission was usually accompanied by recovery of urinary diacetylpolyamines to the normal level… CONTINUE READING

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