Diabodies Targeting Epithelial Membrane Protein 2 Reduce Tumorigenicity of Human Endometrial Cancer Cell Lines

@article{Shimazaki2008DiabodiesTE,
  title={Diabodies Targeting Epithelial Membrane Protein 2 Reduce Tumorigenicity of Human Endometrial Cancer Cell Lines},
  author={K. Shimazaki and E. J. Lepin and B. Wei and A. Nagy and Catherine P Coulam and Sergey Mareninov and M. Fu and A. Wu and J. Marks and J. Braun and L. Gordon and M. Wadehra},
  journal={Clinical Cancer Research},
  year={2008},
  volume={14},
  pages={7367 - 7377}
}
  • K. Shimazaki, E. J. Lepin, +9 authors M. Wadehra
  • Published 2008
  • Biology, Medicine
  • Clinical Cancer Research
  • Purpose: Endometrial cancer is the most common gynecologic malignancy. One promising biomarker is epithelial membrane protein 2 (EMP2), and its expression is an independent prognostic indicator for tumors with poor clinical outcome expression. The present study assesses the suitability of EMP2 as a therapeutic target. Experimental Design: Human monovalent anti-EMP2 antibody fragments were isolated from a human phage display library and engineered as bivalent antibody fragments (diabodies) with… CONTINUE READING
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