Diablo Promotes Apoptosis by Removing Miha/Xiap from Processed Caspase 9

@article{Ekert2001DiabloPA,
  title={Diablo Promotes Apoptosis by Removing Miha/Xiap from Processed Caspase 9},
  author={Paul G Ekert and John Silke and Christine J Hawkins and Anne M. Verhagen and David L. Vaux},
  journal={The Journal of Cell Biology},
  year={2001},
  volume={152},
  pages={483 - 490}
}
MIHA is an inhibitor of apoptosis protein (IAP) that can inhibit cell death by direct interaction with caspases, the effector proteases of apoptosis. DIABLO is a mammalian protein that can bind to IAPs and antagonize their antiapoptotic effect, a function analogous to that of the proapoptotic Drosophila molecules, Grim, Reaper, and HID. Here, we show that after UV radiation, MIHA prevented apoptosis by inhibiting caspase 9 and caspase 3 activation. Unlike Bcl-2, MIHA functioned after release of… CONTINUE READING

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